Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | MAPT | P10636 | 6/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | MTOR | P42345 | 1/20 | 0.38 |
| ▸ | MITF | O75030 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.36 |
| ▸ | RELA | Q04206 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16975409 | 0.82 | POLB (0.46) | ALDH1A1MAPTSMN1; SMN2L3MBTL1POLB | |
| SCHEMBL28187733 | 0.79 | ALDH1A1 (0.43) | ALDH1A1MAPTSMN1; SMN2L3MBTL1POLB | |
| SCHEMBL20555350 | 0.77 | POLB (0.42) | ALDH1A1MAPTSMN1; SMN2MAPK1TDP1 | |
| SCHEMBL26120909 | 0.77 | POLB (0.41) | ALDH1A1SMN1; SMN2MAPK1TDP1L3MBTL1 | |
| SCHEMBL16975579 | 0.77 | ALDH1A1 (0.41) | ALDH1A1MAPTSMN1; SMN2MAPK1L3MBTL1 | |
| SCHEMBL20555279 | 0.77 | POLB (0.40) | ALDH1A1SMN1; SMN2MAPK1L3MBTL1POLB | |
| SCHEMBL27439921 | 0.76 | ALDH1A1 (0.40) | ALDH1A1SMN1; SMN2L3MBTL1POLBKMT2A | |
| SCHEMBL9332638 | 0.74 | MAPT (0.51) | ALDH1A1MAPTSMN1; SMN2MAPK1TDP1 | |
| SCHEMBL30908417 | 0.73 | ALDH1A1 (0.50) | ALDH1A1MAPTSMN1; SMN2MAPK1POLB | |
| SCHEMBL26120935 | 0.72 | POLB (0.40) | ALDH1A1MAPTSMN1; SMN2TDP1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220119371-A1 | COMPOUND, COMPOSITIONS, AND METHODS | DENALI THERAPEUTICS INC. (US) | 2022-04-21 | — | — | US | disclosed |
| US-11214565-B2 | Compound, compositions, and methods | DENALI THERAPEUTICS INC. (US) | 2022-01-04 | — | — | US | disclosed |
| US-20180327391-A1 | COMPOUND, COMPOSITIONS, AND METHODS | DENALI THERAPEUTICS INC. | 2018-11-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180327391-A1 | COMPOUND, COMPOSITIONS, AND METHODS | LRRK2, PARK7, MAPT | ALDH1A1 3433/4885MAPT 3/4885SMN1; SMN2 76/4885 |
| US-20220119371-A1 | COMPOUND, COMPOSITIONS, AND METHODS | LRRK2, PARK7, SNCA | ALDH1A1 3312/4885MAPT 5/4885SMN1; SMN2 78/4885 |
| US-11214565-B2 | Compound, compositions, and methods | LRRK2, PARK7, MAPT | ALDH1A1 3433/4885MAPT 3/4885SMN1; SMN2 76/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.