Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.40 |
| ▸ | IDO1 | P14902 | 2/20 | 0.39 |
| ▸ | AGXT | P21549 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | DAO | P14920 | 1/20 | 0.38 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.38 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.36 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.36 |
| ▸ | MIF | P14174 | 1/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.36 |
| ▸ | MPO | P05164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1255674 | 0.72 | MPO (0.36) | MPO | |
| SCHEMBL3300303 | 0.72 | TAAR1 (0.60) | TAAR1IDO1AGXTALDH1A1DAO | |
| SCHEMBL17028856 | 0.69 | HSP90AB1 (0.42) | TAAR1IDO1MEN1KMT2AALDH1A1 | |
| SCHEMBL2092840 | 0.69 | CA2 (0.56) | KDM4EALDH1A1LMNAMAPTHPGD | |
| SCHEMBL4212164 | 0.68 | KDM4E (0.61) | TAAR1IDO1AGXTMEN1KMT2A | |
| SCHEMBL6050957 | 0.68 | KDM4E (0.51) | TAAR1IDO1MEN1KMT2AKDM4E | |
| SCHEMBL6235370 | 0.68 | IDO1 (0.42) | TAAR1IDO1AGXTMEN1KMT2A | |
| SCHEMBL28816893 | 0.67 | NPC1 (0.50) | TAAR1IDO1AGXTTLR8TLR7 | |
| SCHEMBL4677 | 0.67 | TAAR1 (0.42) | TAAR1IDO1AGXTKDM4EDAO | |
| SCHEMBL3298408 | 0.67 | CALM1 (0.57) | TAAR1IDO1AGXTALDH1A1DAO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8088806-B2 | Thiazole compounds and methods of use | ACHILLION PHARMACEUTICALS, INC. (US) | 2012-01-03 | — | — | US | disclosed |