Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.72 |
| ▸ | MEN1 | O00255 | 1/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.72 |
| ▸ | TSHR | P16473 | 1/20 | 0.72 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | BTK | Q06187 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | FNTA | P49354 | 1/20 | 0.40 |
| ▸ | FNTB | P49356 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | MMP1 | P03956 | 1/20 | 0.39 |
| ▸ | MMP9 | P14780 | 1/20 | 0.39 |
| ▸ | MMP13 | P45452 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20564928 | 0.87 | ALDH1A1 (0.79) | KMT2AMEN1ALDH1A1TSHRSIGMAR1 | |
| SCHEMBL15841183 | 0.85 | ALDH1A1 (0.67) | KMT2AMEN1ALDH1A1TSHRSIGMAR1 | |
| SCHEMBL22859865 | 0.85 | MEN1 (0.67) | KMT2AMEN1ALDH1A1TSHRSIGMAR1 | |
| SCHEMBL14395969 | 0.84 | MEN1 (0.66) | KMT2AMEN1ALDH1A1TSHRSIGMAR1 | |
| SCHEMBL24447412 | 0.84 | ALDH1A1 (0.56) | KMT2AMEN1ALDH1A1TSHRSIGMAR1 | |
| SCHEMBL21431236 | 0.84 | ALDH1A1 (0.56) | KMT2AMEN1ALDH1A1TSHRSIGMAR1 | |
| SCHEMBL13369184 | 0.84 | SIGMAR1 (0.55) | KMT2AMEN1ALDH1A1TSHRSIGMAR1 | |
| SCHEMBL23462520 | 0.83 | MEN1 (0.65) | KMT2AMEN1ALDH1A1TSHRSIGMAR1 | |
| SCHEMBL28046106 | 0.83 | MEN1 (0.65) | KMT2AMEN1ALDH1A1TSHRSIGMAR1 | |
| SCHEMBL22859758 | 0.83 | ALDH1A1 (0.64) | KMT2AMEN1ALDH1A1TSHRSIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110891951-B | Compounds of formula (I) | 谢菲尔德大学 | 2024-08-20 | — | — | CN | disclosed |
| EP-3628045-B1 | COMPOUNDS | UNIV SHEFFIELD (GB) | 2024-07-03 | — | — | EP | disclosed |
| EP-3628045-B1 | COMPOUNDS | UNIV SHEFFIELD (GB) | 2024-07-03 | — | — | EP | disclosed |
| US-11400081-B2 | Compounds | THE UNIVERSITY OF SHEFFIELD (GB) | 2022-08-02 | — | — | US | disclosed |
| US-20210113534-A1 | COMPOUNDS | THE UNIVERSITY OF SHEFFIELD (GB) | 2021-04-22 | — | — | US | disclosed |
| US-20210113534-A1 | COMPOUNDS | THE UNIVERSITY OF SHEFFIELD (GB) | 2021-04-22 | — | — | US | disclosed |
| EP-3628045-A1 | COMPOUNDS | The University Of Sheffield (GB) | 2020-04-01 | — | — | EP | disclosed |
| CN-110891951-A | Compound (I) | 谢菲尔德大学 | 2020-03-17 | — | — | CN | disclosed |
| WO-2018211275-A1 | COMPOUNDS | THE UNIVERSITY OF SHEFFIELD (GB) | 2018-11-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210113534-A1 | COMPOUNDS | MRGPRX2, MC2R, ADM2 | KMT2A 4639/4885MEN1 11/4885ALDH1A1 1907/4885 |
| US-11400081-B2 | Compounds | MRGPRX2, MC2R, ADM2 | KMT2A 4639/4885MEN1 11/4885ALDH1A1 1907/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.