Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 8/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.37 |
| ▸ | USP2 | O75604 | 3/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.37 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 7/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL933548 | 0.85 | USP2 (0.41) | CYP2D6CYP1A2CYP2C9USP2CHRM2 | |
| SCHEMBL346850 | 0.84 | CYP1A2 (0.42) | CYP2D6CYP1A2CYP2C9USP2CYP2C19 | |
| SCHEMBL1723498 | 0.83 | ALDH1A1 (0.33) | CYP1A2ALDH1A1 | |
| SCHEMBL8223931 | 0.82 | HSD11B1 (0.41) | CYP2D6CYP1A2CYP2C9USP2CYP2C19 | |
| SCHEMBL3924590 | 0.81 | HSD11B1 (0.42) | CYP2D6CYP1A2CYP2C9USP2CYP2C19 | |
| SCHEMBL751237 | 0.81 | USP2 (0.39) | CYP2D6CYP1A2CYP2C9USP2CYP2C19 | |
| Hydrochloric Acid SCHEMBL19210209 | 0.80 | ALDH1A1 (0.32) | ALDH1A1 | |
| SCHEMBL4062010 | 0.79 | HSD11B1 (0.45) | CYP1A2CYP2C9USP2CYP2C19CYP3A4 | |
| Hydrochloric Acid SCHEMBL8486057 | 0.79 | HSD11B1 (0.41) | CYP2D6CYP1A2CYP2C9USP2CYP2C19 | |
| SCHEMBL30501211 | 0.77 | USP2 (0.37) | CYP2D6CYP1A2CYP2C9USP2CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3628045-B1 | COMPOUNDS | UNIV SHEFFIELD (GB) | 2024-07-03 | — | — | EP | disclosed |
| US-20210113534-A1 | COMPOUNDS | THE UNIVERSITY OF SHEFFIELD (GB) | 2021-04-22 | — | — | US | disclosed |
| EP-3628045-A1 | COMPOUNDS | The University Of Sheffield (GB) | 2020-04-01 | — | — | EP | disclosed |
| WO-2018211275-A1 | COMPOUNDS | THE UNIVERSITY OF SHEFFIELD (GB) | 2018-11-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210113534-A1 | COMPOUNDS | MRGPRX2, MC2R, ADM2 | CYP2D6 838/4885CYP1A2 465/4885CYP2C9 795/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.