Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 3/20 | 0.62 |
| ▸ | RAB9A | P51151 | 2/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | HTR2A | P28223 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | BCL9 | O00512 | 1/20 | 0.47 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | AGXT | P21549 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1714950 | 0.86 | HTR2A (0.70) | RAB9ANPC1HTR2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL20377184 | 0.83 | SMN1; SMN2 (0.64) | SMN1; SMN2ALDH1A1LMNABCL9CTNNB1 | |
| SCHEMBL6322393 | 0.83 | SMN1; SMN2 (0.64) | SMN1; SMN2ALDH1A1LMNABCL9CTNNB1 | |
| SCHEMBL7440434 | 0.83 | HTR2A (0.53) | RAB9ANPC1HTR2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL16695904 | 0.83 | HTR2A (0.56) | RAB9ANPC1HTR2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL27189134 | 0.80 | HTR2A (0.59) | RAB9ANPC1HTR2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL14437515 | 0.80 | HTR2A (0.66) | RAB9AHTR2ASMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL4644851 | 0.80 | HTR2A (0.56) | RAB9ANPC1HTR2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL26374 | 0.80 | GAA (0.65) | RAB9ANPC1HTR2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL17022709 | 0.79 | POLB (0.63) | SMN1; SMN2ALDH1A1LMNABCL9CTNNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3625209-A1 | BIS-OCTAHYDROPHENANTHRENE CARBOXAMIDES AND PROTEIN CONJUGATES THEREOF | Regeneron Pharmaceuticals, Inc. (US) | 2020-03-25 | — | — | EP | disclosed |
| WO-2018213082-A1 | BIS-OCTAHYDROPHENANTHRENE CARBOXAMIDES AND PROTEIN CONJUGATES THEREOF | REGENERON PHARMACEUTICALS, INC. (US) | 2018-11-22 | — | — | WO | disclosed |