Sugi Predict

Sugi Predict / Compounds / SCHEMBL20565486

SCHEMBL20565486

SCHEMBL20565486

CCOC(=O)c1cc(OC(C)=O)c2cc(Br)cc(OC)c2c1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ HSD17B2 P37059 1/20 0.47
▸ CA12 O43570 1/20 0.41
▸ CA1 P00915 1/20 0.41
▸ CA2 P00918 1/20 0.41
▸ CA7 P43166 1/20 0.41
▸ CA9 Q16790 1/20 0.41
▸ CA14 Q9ULX7 1/20 0.41
▸ LMNA P02545 2/20 0.40
▸ L3MBTL1 Q9Y468 1/20 0.40
▸ TSHR P16473 1/20 0.40
▸ ALDH1A1 P00352 4/20 0.39
▸ CYP1A2 P05177 1/20 0.39
▸ CYP2C19 P33261 1/20 0.39
▸ NPC1 O15118 1/20 0.39
▸ RAB9A P51151 1/20 0.39
▸ SMN1; SMN2 Q16637 1/20 0.39
▸ MAPT P10636 3/20 0.38
▸ MEN1 O00255 2/20 0.38
▸ KMT2A Q03164 2/20 0.38
▸ GAA P10253 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10393725 0.82 HSD17B2 (0.47) HSD17B2ALDH1A1SMN1; SMN2MEN1KMT2A
SCHEMBL6042081 0.82 CDC25B (0.52) HSD17B2CA12CA1CA2CA7
SCHEMBL2390084 0.80 ALDH1A1 (0.46) HSD17B2CA12CA1CA2CA7
SCHEMBL10394100 0.79 HSD17B2 (0.46) HSD17B2TSHRALDH1A1SMN1; SMN2MAPT
SCHEMBL10394316 0.78 HSD17B2 (0.51) HSD17B2CA12CA1CA2CA7
SCHEMBL13005288 0.77 ALDH1A1 (0.43) HSD17B2CA12CA1CA2CA7
SCHEMBL2390984 0.76 HSD17B2 (0.52) HSD17B2CA12CA1CA2CA7
SCHEMBL10394356 0.76 HSD17B2 (0.43) HSD17B2CA12CA1CA2CA7
SCHEMBL10317176 0.76 HSD17B2 (0.61) HSD17B2CA12CA1CA2CA7
SCHEMBL4647233 0.75 HSD17B2 (0.66) HSD17B2CA12CA1CA2CA7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12195424-B2 Antibiotic compounds THE GENERAL HOSPITAL CORPORATION (US) 2025-01-14 — — US disclosed
US-20220095614-A1 Antibiotic Compounds THE GENERAL HOSPITAL CORPORATION 2022-03-31 — — US disclosed
US-20220095614-A1 Antibiotic Compounds THE GENERAL HOSPITAL CORPORATION 2022-03-31 — — US disclosed
US-11278025-B2 Antibiotic compounds THE GENERAL HOSPITAL CORPORATION (US) 2022-03-22 — — US disclosed
US-20200190009-A1 Antibiotic Compounds TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION 2020-06-18 — — US disclosed
WO-2018213609-A1 ANTIBIOTIC COMPOUNDS AUSUBEL FREDERICK M (US) 2018-11-22 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200190009-A1 Antibiotic Compounds CUTA, NRDC, CLPP HSD17B2 96/4885CA12 4426/4885CA1 4884/4885
US-20220095614-A1 Antibiotic Compounds CUTA, NRDC, CLPP HSD17B2 96/4885CA12 4426/4885CA1 4884/4885
US-12195424-B2 Antibiotic compounds CUTA, NRDC, CLPP HSD17B2 96/4885CA12 4426/4885CA1 4884/4885
US-11278025-B2 Antibiotic compounds CUTA, NRDC, CLPP HSD17B2 96/4885CA12 4426/4885CA1 4884/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.