Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.46 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.41 |
| ▸ | ACP1 | P24666 | 1/20 | 0.40 |
| ▸ | CES2 | O00748 | 3/20 | 0.38 |
| ▸ | TACR1 | P25103 | 2/20 | 0.38 |
| ▸ | TMPRSS4 | Q9NRS4 | 2/20 | 0.36 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.36 |
| ▸ | RXRA | P19793 | 2/20 | 0.35 |
| ▸ | RXRB | P28702 | 2/20 | 0.35 |
| ▸ | RXRG | P48443 | 1/20 | 0.35 |
| ▸ | P2RX4 | Q99571 | 2/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12397947 | 0.78 | NOTUM (0.47) | NOTUMTAS2R14ACP1CES2TACR1 | |
| SCHEMBL1410175 | 0.76 | NOTUM (0.47) | NOTUMTAS2R14ACP1CES2TACR1 | |
| SCHEMBL12436182 | 0.75 | NOTUM (0.46) | NOTUMTAS2R14ACP1CES2TACR1 | |
| SCHEMBL6815372 | 0.73 | NOTUM (0.43) | NOTUMTAS2R14ACP1CES2TACR1 | |
| SCHEMBL30503556 | 0.73 | NOTUM (0.43) | NOTUMTAS2R14ACP1CES2TACR1 | |
| SCHEMBL494019 | 0.72 | NOTUM (0.64) | NOTUMTAS2R14ACP1CES2GPR35 | |
| SCHEMBL1973258 | 0.72 | MMP1 (0.39) | TMPRSS4L3MBTL1P2RX1LMNA | |
| SCHEMBL1973255 | 0.72 | MMP1 (0.39) | TMPRSS4L3MBTL1P2RX1LMNA | |
| SCHEMBL20568968 | 0.71 | TACR1 (0.43) | TACR1 | |
| SCHEMBL1082212 | 0.71 | NOTUM (0.50) | NOTUMTAS2R14ACP1CES2TMPRSS4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3630778-A1 | NOVEL INHIBITORS OF MAP4K1 | Ichnos Sciences SA (CH) | 2020-04-08 | — | — | EP | disclosed |
| WO-2018215668-A1 | NOVEL INHIBITORS OF MAP4K1 | GLENMARK PHARMACEUTICALS S.A. (CH) | 2018-11-29 | — | — | WO | disclosed |