Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC2 | Q92769 | 4/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.40 |
| ▸ | NR1H2 | P55055 | 4/20 | 0.36 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | MMP13 | P45452 | 1/20 | 0.35 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.34 |
| ▸ | ASAH1 | Q13510 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.34 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.34 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.34 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.33 |
| ▸ | IKBKB | O14920 | 1/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | MTOR | P42345 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30220573 | 0.91 | MAPK14 (0.35) | NR1H2NR1H3MAPK14KDM4EMAPT | |
| SCHEMBL20571060 | 0.88 | PLA2G2A (0.40) | NR1H2NR1H3 | |
| SCHEMBL20495119 | 0.88 | HDAC2 (0.40) | HDAC2HDAC1NR1H2NR1H3MAPK14 | |
| SCHEMBL30071433 | 0.88 | HDAC2 (0.40) | HDAC2HDAC1NR1H2NR1H3MAPK14 | |
| SCHEMBL20569958 | 0.84 | HDAC2 (0.38) | HDAC2HDAC1NR1H2NR1H3MAPK14 | |
| SCHEMBL20571558 | 0.83 | HDAC2 (0.41) | HDAC2HDAC1NR1H2NR1H3MMP13 | |
| SCHEMBL3028022 | 0.83 | HTR6 (0.38) | NR1H2KDM4EMAPT | |
| SCHEMBL20570902 | 0.82 | GPR119 (0.39) | HDAC2HDAC1NR1H2NR1H3MAPK14 | |
| SCHEMBL20571067 | 0.81 | PLA2G2A (0.43) | NR1H2NR1H3 | |
| SCHEMBL20570828 | 0.79 | KDM4E (0.42) | KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11826357-B2 | Bacterial efflux pump inhibitors | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 2023-11-28 | — | — | US | disclosed |
| US-11826357-B2 | Bacterial efflux pump inhibitors | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 2023-11-28 | — | — | US | disclosed |
| US-20200197382-A1 | BACTERIAL EFFLUX PUMP INHIBITORS | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 2020-06-25 | — | — | US | disclosed |
| CN-111163774-A | Bacterial efflux pump inhibitors | 罗格斯新泽西州立大学 | 2020-05-15 | — | — | CN | disclosed |
| EP-3630109-A1 | BACTERIAL EFFLUX PUMP INHIBITORS | Rutgers, the State University of New Jersey (US) | 2020-04-08 | — | — | EP | disclosed |
| WO-2018218192-A1 | BACTERIAL EFFLUX PUMP INHIBITORS | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 2018-11-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200197382-A1 | BACTERIAL EFFLUX PUMP INHIBITORS | ABCB11, ABCB1, SLC47A1 | HDAC2 3111/4885HDAC1 1634/4885NR1H2 583/4885 |
| US-11826357-B2 | Bacterial efflux pump inhibitors | ABCB11, ABCB1, SLC47A1 | HDAC2 3111/4885HDAC1 1634/4885NR1H2 583/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.