Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN11 | Q06124 | 1/20 | 0.45 |
| ▸ | MPL | P40238 | 3/20 | 0.42 |
| ▸ | REV1 | Q9UBZ9 | 1/20 | 0.42 |
| ▸ | BCAT1 | P54687 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.40 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.39 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.38 |
| ▸ | DPP4 | P27487 | 1/20 | 0.37 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.36 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20569929 | 0.83 | ADORA2A (0.55) | MPLADORA2ADPP4KDM4EALDH1A1 | |
| SCHEMBL29256283 | 0.81 | PIK3R1 (0.44) | PTPN11MPLREV1BCAT1DYRK1A | |
| SCHEMBL30883063 | 0.81 | PIK3R1 (0.44) | PTPN11MPLREV1BCAT1DYRK1A | |
| SCHEMBL28092741 | 0.80 | PTPN11 (0.46) | PTPN11MPLREV1BCAT1DYRK1A | |
| SCHEMBL4012175 | 0.80 | CYP2D6 (0.57) | PTPN11MPLREV1BCAT1DYRK1A | |
| SCHEMBL3038641 | 0.79 | CES2 (0.46) | MPLBCAT1CCNE2CCNE1CDK2 | |
| SCHEMBL28658223 | 0.77 | MPL (0.49) | PTPN11MPLSMN1; SMN2DYRK1APIK3R1 | |
| SCHEMBL2496171 | 0.76 | MPL (0.38) | PTPN11MPLREV1BCAT1SMN1; SMN2 | |
| SCHEMBL9131702 | 0.75 | ADORA2A (0.41) | PTPN11MPLREV1SMN1; SMN2DYRK1A | |
| SCHEMBL398474 | 0.74 | ALDH1A1 (0.59) | MPLREV1SMN1; SMN2ADORA2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11896591-B2 | Compositions and methods for preparing and using mitochondrial uncouplers | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) | 2024-02-13 | — | — | US | disclosed |
| US-20200323846-A1 | COMPOSITIONS AND METHODS FOR PREPARING AND USING MITOCHONDRIAL UNCOUPLERS | UNIVERSITY OF VIRGINA PATENT FOUNDATION (US) | 2020-10-15 | — | — | US | disclosed |
| EP-3630115-A1 | COMPOSITIONS AND METHODS FOR PREPARING AND USING MITOCHONDRIAL UNCOUPLERS | University Of Virginia Patent Foundation (US) | 2020-04-08 | — | — | EP | disclosed |
| WO-2018217757-A1 | COMPOSITIONS AND METHODS FOR PREPARING AND USING MITOCHONDRIAL UNCOUPLERS | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) | 2018-11-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11896591-B2 | Compositions and methods for preparing and using mitochondrial uncouplers | ACAD9, GPR119, NDUFAF1 | PTPN11 475/4885MPL 4437/4885REV1 2907/4885 |
| US-20200323846-A1 | COMPOSITIONS AND METHODS FOR PREPARING AND USING MITOCHONDRIAL UNCOUPLERS | ACAD9, GPR119, NDUFAF1 | PTPN11 475/4885MPL 4437/4885REV1 2907/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.