Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VCAM1 | P19320 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 5/20 | 0.46 |
| ▸ | MERTK | Q12866 | 2/20 | 0.44 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.38 |
| ▸ | EIF4E | P06730 | 1/20 | 0.38 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.38 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.38 |
| ▸ | EP300 | Q09472 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6113831 | 0.88 | VCAM1 (0.54) | VCAM1MAPTMERTKPDK1KMT2A | |
| SCHEMBL31431218 | 0.86 | VCAM1 (0.46) | VCAM1MAPTMERTKKMT2AMEN1 | |
| SCHEMBL15174209 | 0.85 | VCAM1 (0.50) | VCAM1MAPTMERTKKMT2AMEN1 | |
| SCHEMBL224136 | 0.83 | VCAM1 (0.54) | VCAM1MAPTMERTKKMT2AMEN1 | |
| SCHEMBL2368600 | 0.81 | VCAM1 (0.47) | VCAM1MAPTMERTKKMT2AMEN1 | |
| SCHEMBL31432402 | 0.79 | TRPV4 (0.54) | VCAM1MAPTMERTKKMT2AMEN1 | |
| SCHEMBL28596701 | 0.78 | VCAM1 (0.53) | VCAM1MAPTMERTKPDK1KMT2A | |
| SCHEMBL28870755 | 0.78 | PDK1 (0.51) | MAPTPDK1KMT2AMEN1MAPK1 | |
| SCHEMBL1340227 | 0.78 | TSHR (0.56) | MAPTPDK1KMT2AMEN1MAPK1 | |
| SCHEMBL31432638 | 0.77 | MAPT (0.53) | VCAM1MAPTMERTKKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119775274-A | 4-Anilino substituted pyrido [3,2-d ] pyrimidine compound and application thereof | 沈阳药科大学 | 2025-04-08 | — | — | CN | disclosed |
| EP-3792264-B1 | PYRROPYRIMIDINE COMPOUNDS AS MNKS INHIBITORS | LIFEARC (GB) | 2024-01-03 | — | — | EP | disclosed |
| CN-108368114-B | Pyrrolopyrimidine compounds as MNK inhibitors | 生命弧度公司 | 2023-10-24 | — | — | CN | disclosed |
| EP-3792264-A1 | PYRROPYRIMIDINE COMPOUNDS AS MNKS INHIBITORS | LifeArc (GB) | 2021-03-17 | — | — | EP | disclosed |
| EP-3377494-B1 | PYRROPYRIMIDINE COMPOUNDS AS MNKS INHIBITORS | LIFEARC (GB) | 2021-03-03 | — | — | EP | disclosed |
| EP-3377494-B1 | PYRROPYRIMIDINE COMPOUNDS AS MNKS INHIBITORS | LIFEARC (GB) | 2021-03-03 | — | — | EP | disclosed |
| US-10604524-B2 | Pyrropyrimidine compounds as MNKs inhibitors | LIFE ARC (GB) | 2020-03-31 | — | — | US | disclosed |
| US-20180346469-A1 | Pyrropyrimidine Compounds As MNKS Inhibitors | MEDICAL RESEARCH COUNCIL TECHNOLOGY (GB) | 2018-12-06 | — | — | US | disclosed |
| CN-108368114-A | Pyrrolopyrimidine compounds as MNK inhibitor | 生命弧度公司 | 2018-08-03 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180346469-A1 | Pyrropyrimidine Compounds As MNKS Inhibitors | NR0B1, NR4A1, NR2E1 | VCAM1 3232/4885MAPT 60/4885MERTK 252/4885 |
| US-10604524-B2 | Pyrropyrimidine compounds as MNKs inhibitors | NR0B1, NR2E1, HRH4 | VCAM1 3063/4885MAPT 36/4885MERTK 280/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.