Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 10/20 | 0.35 |
| ▸ | KIT | P10721 | 7/20 | 0.35 |
| ▸ | CHEK1 | O14757 | 6/20 | 0.35 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.35 |
| ▸ | CCNC | P24863 | 1/20 | 0.35 |
| ▸ | CDK8 | P49336 | 1/20 | 0.35 |
| ▸ | CSF1R | P07333 | 2/20 | 0.35 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.33 |
| ▸ | CDK1 | P06493 | 1/20 | 0.33 |
| ▸ | CDK4 | P11802 | 1/20 | 0.33 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.33 |
| ▸ | CCND1 | P24385 | 1/20 | 0.33 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | CCND3 | P30281 | 1/20 | 0.33 |
| ▸ | CDK7 | P50613 | 1/20 | 0.33 |
| ▸ | CDK9 | P50750 | 1/20 | 0.33 |
| ▸ | CCNH | P51946 | 1/20 | 0.33 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20576247 | 1.00 | FLT3 (0.35) | FLT3KITCHEK1ADORA2BADORA1 | |
| SCHEMBL20576817 | 0.91 | NTRK1 (0.37) | FLT3KITCHEK1ADORA2BADORA1 | |
| SCHEMBL20576815 | 0.91 | NTRK1 (0.37) | FLT3KITCHEK1ADORA2BADORA1 | |
| SCHEMBL20576566 | 0.90 | ADORA2B (0.43) | FLT3KITCHEK1ADORA2BADORA1 | |
| SCHEMBL20576568 | 0.90 | ADORA2B (0.43) | FLT3KITCHEK1ADORA2BADORA1 | |
| SCHEMBL21350949 | 0.89 | ABL1 (0.45) | FLT3KITCDK8 | |
| SCHEMBL20575926 | 0.88 | RIPK1 (0.43) | ADORA2BADORA1CCNT1CDK1 | |
| SCHEMBL20575924 | 0.88 | RIPK1 (0.43) | ADORA2BADORA1CCNT1CDK1 | |
| SCHEMBL20576535 | 0.88 | AXL (0.37) | FLT3KITCHEK1ADORA2BADORA1 | |
| SCHEMBL20576534 | 0.88 | AXL (0.37) | FLT3KITCHEK1ADORA2BADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10392367-B2 | IRE1 small molecule inhibitors | QUENTIS THERAPEUTICS, INC. (US) | 2019-08-27 | — | — | US | claimed |
| US-20180346447-A1 | IRE1 SMALL MOLECULE INHIBITORS | CORNELL UNIVERSITY | 2018-12-06 | — | — | US | claimed |
| US-10392367-B2 | IRE1 small molecule inhibitors | QUENTIS THERAPEUTICS, INC. (US) | 2019-08-27 | — | — | US | disclosed |
| US-20180346447-A1 | IRE1 SMALL MOLECULE INHIBITORS | CORNELL UNIVERSITY | 2018-12-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10392367-B2 | IRE1 small molecule inhibitors | XBP1, ERN2, ERN1 | FLT3 2637/4885KIT 4681/4885CHEK1 957/4885 |
| US-20180346447-A1 | IRE1 SMALL MOLECULE INHIBITORS | XBP1, ERN2, ERN1 | FLT3 2637/4885KIT 4681/4885CHEK1 957/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.