Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | RAB9A | P51151 | 10/20 | 0.49 |
| ▸ | NPC1 | O15118 | 9/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | STK17B | O94768 | 1/20 | 0.41 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | MIF | P14174 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 3/20 | 0.36 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | ATR | Q13535 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20581090 | 1.00 | L3MBTL1 (0.50) | L3MBTL1MAPTRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL10801436 | 0.81 | L3MBTL1 (0.54) | L3MBTL1MAPTRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL20582091 | 0.79 | MAPT (0.43) | L3MBTL1MAPTRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL20581110 | 0.78 | L3MBTL1 (0.51) | L3MBTL1MAPTRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL20581109 | 0.78 | L3MBTL1 (0.51) | L3MBTL1MAPTRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL10805983 | 0.77 | L3MBTL1 (0.65) | L3MBTL1MAPTRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL21431899 | 0.76 | L3MBTL1 (0.55) | L3MBTL1MAPTRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL20583911 | 0.75 | GAA (0.61) | L3MBTL1MAPTRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL20583909 | 0.75 | GAA (0.61) | L3MBTL1MAPTRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL29544846 | 0.75 | GAA (0.61) | L3MBTL1MAPTRAB9ANPC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12247031-B2 | Cyclobutyl pyrazolopyrimidine PDE9 inhibitors | MERCK SHARP & DOHME LLC (US) | 2025-03-11 | — | — | US | disclosed |
| EP-3893881-B1 | CYCLOBUTYL PYRAZOLOPYRIMIDINE PDE9 INHIBITORS | MERCK SHARP & DOHME LLC (US) | 2024-10-09 | — | — | EP | disclosed |
| EP-3634964-B1 | PYRAZOLOPYRIMIDINE PDE9 INHIBITORS | MERCK SHARP & DOHME (US) | 2022-02-23 | — | — | EP | disclosed |
| US-20220017525-A1 | CYCLOBUTYL PYRAZOLOPYRIMIDINE PDE9 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2022-01-20 | — | — | US | disclosed |
| US-11028092-B2 | Substituted pyrazolo[3,4-d]pyrimidines as PDE9 inhibitors | MERCK SHARP & DOHME CORP. (US) | 2021-06-08 | — | — | US | disclosed |
| US-10934294-B2 | Substituted pyrazolo[3,4-d]pyrimidines as PDE9 inhibitors | MERCK SHARP & DOHME CORP. (US) | 2021-03-02 | — | — | US | disclosed |
| US-20200140445-A1 | PYRAZOLOPYRIMIDINE PDE9 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2020-05-07 | — | — | US | disclosed |
| US-20180354955-A1 | PYRAZOLOPYRIMIDINE PDE9 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2018-12-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10934294-B2 | Substituted pyrazolo[3,4-d]pyrimidines as PDE9 inhibitors | PDE9A, PDE5A, PDE4D | L3MBTL1 4551/4885MAPT 1894/4885RAB9A 52/4885 |
| US-20200140445-A1 | PYRAZOLOPYRIMIDINE PDE9 INHIBITORS | PDE9A, PDE5A, PDE2A | L3MBTL1 4575/4885MAPT 2036/4885RAB9A 60/4885 |
| US-20220017525-A1 | CYCLOBUTYL PYRAZOLOPYRIMIDINE PDE9 INHIBITORS | PDE9A, PDE5A, PDE3B | L3MBTL1 4207/4885MAPT 2144/4885RAB9A 69/4885 |
| US-11028092-B2 | Substituted pyrazolo[3,4-d]pyrimidines as PDE9 inhibitors | PDE9A, PDE5A, PDE4D | L3MBTL1 4551/4885MAPT 1894/4885RAB9A 52/4885 |
| US-12247031-B2 | Cyclobutyl pyrazolopyrimidine PDE9 inhibitors | PDE9A, PDE5A, PDE3B | L3MBTL1 4207/4885MAPT 2144/4885RAB9A 69/4885 |
| US-20180354955-A1 | PYRAZOLOPYRIMIDINE PDE9 INHIBITORS | PDE9A, PDE5A, PDE12 | L3MBTL1 4279/4885MAPT 2290/4885RAB9A 87/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.