Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 8/20 | 0.41 |
| ▸ | RAB9A | P51151 | 5/20 | 0.41 |
| ▸ | GAA | P10253 | 5/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20581393 | 0.79 | L3MBTL1 (0.50) | MAPTLMNACYP1A2CYP2C9CYP2C19 | |
| SCHEMBL20581090 | 0.79 | L3MBTL1 (0.50) | MAPTLMNACYP1A2CYP2C9CYP2C19 | |
| SCHEMBL9795934 | 0.78 | ALDH1A1 (0.56) | MAPTPOLBLMNANPC1RAB9A | |
| SCHEMBL9795932 | 0.78 | ALDH1A1 (0.56) | MAPTPOLBLMNANPC1RAB9A | |
| SCHEMBL28825655 | 0.75 | LMNA (0.72) | MAPTPOLBLMNACYP1A2CYP2C9 | |
| SCHEMBL14938560 | 0.72 | MAPT (0.78) | MAPTPOLBLMNACYP1A2CYP2C9 | |
| SCHEMBL9768862 | 0.71 | NPC1 (0.61) | MAPTNPC1RAB9AGAAALDH1A1 | |
| SCHEMBL9768867 | 0.71 | NPC1 (0.61) | MAPTNPC1RAB9AGAAALDH1A1 | |
| SCHEMBL600134 | 0.71 | NAPRT (0.40) | MAPTLMNANPC1RAB9AALDH1A1 | |
| Hydrochloric Acid SCHEMBL9769046 | 0.70 | NPC1 (0.60) | MAPTNPC1RAB9AGAAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3634964-A1 | PYRAZOLOPYRIMIDINE PDE9 INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2020-04-15 | — | — | EP | disclosed |
| WO-2018226771-A1 | PYRAZOLOPYRIMIDINE PDE9 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2018-12-13 | — | — | WO | disclosed |