Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 7/20 | 0.35 |
| ▸ | AXL | P30530 | 4/20 | 0.35 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.35 |
| ▸ | MERTK | Q12866 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | APAF1 | O14727 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.33 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20587523 | 0.95 | MAP4K1 (0.35) | METAXLTYRO3MERTKALDH1A1 | |
| SCHEMBL20588595 | 0.93 | MAP4K1 (0.34) | METAXLSMN1; SMN2MAP4K1RAB9A | |
| SCHEMBL20587612 | 0.91 | ROCK2 (0.33) | METAXLSMN1; SMN2MAP4K1RAB9A | |
| SCHEMBL20588120 | 0.91 | ROCK2 (0.40) | METAXLTYRO3MERTKALDH1A1 | |
| SCHEMBL20588349 | 0.90 | MAP4K1 (0.35) | METAXLSMN1; SMN2MAP4K1RAB9A | |
| SCHEMBL20588589 | 0.90 | MAP4K1 (0.40) | METAXLTYRO3MERTKMAP4K1 | |
| SCHEMBL20588769 | 0.90 | ROCK2 (0.34) | METAXLMAP4K1KDRRET | |
| SCHEMBL20588441 | 0.90 | ROCK2 (0.32) | METAXLSMN1; SMN2MAP4K1RAB9A | |
| SCHEMBL20588354 | 0.90 | TBK1 (0.36) | METAXLMAP4K1KDRTBK1 | |
| SCHEMBL20587966 | 0.89 | TBK1 (0.35) | METAXLMAP4K1TBK1ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3638669-A1 | SUBSTITUTED PYRROLOPYRIDINE-DERIVATIVES | Bayer Pharma Aktiengesellschaft (DE) | 2020-04-22 | — | — | EP | disclosed |
| WO-2018228920-A1 | SUBSTITUTED PYRROLOPYRIDINE-DERIVATIVES | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2018-12-20 | — | — | WO | disclosed |