Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 1/20 | 0.32 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.32 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.32 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.32 |
| ▸ | MET | P08581 | 3/20 | 0.31 |
| ▸ | BRAF | P15056 | 1/20 | 0.30 |
| ▸ | EGFR | P00533 | 1/20 | 0.30 |
| ▸ | IGF1R | P08069 | 1/20 | 0.30 |
| ▸ | KIT | P10721 | 1/20 | 0.30 |
| ▸ | SRC | P12931 | 1/20 | 0.30 |
| ▸ | AXL | P30530 | 1/20 | 0.30 |
| ▸ | KDR | P35968 | 1/20 | 0.30 |
| ▸ | MST1R | Q04912 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.30 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.30 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20588595 | 0.92 | MAP4K1 (0.34) | ROCK2OPRK1MAP4K1TBK1MET | |
| SCHEMBL20587700 | 0.91 | MAP4K1 (0.36) | ROCK2OPRK1MAP4K1TBK1MET | |
| SCHEMBL20588297 | 0.91 | MAP4K1 (0.38) | ROCK2OPRK1MAP4K1TBK1MET | |
| SCHEMBL20588679 | 0.90 | MET (0.35) | ROCK2OPRK1MAP4K1TBK1MET | |
| SCHEMBL20587523 | 0.88 | MAP4K1 (0.35) | ROCK2OPRK1MAP4K1TBK1MET | |
| SCHEMBL20587612 | 0.88 | ROCK2 (0.33) | ROCK2OPRK1MAP4K1TBK1MET | |
| SCHEMBL20588349 | 0.88 | MAP4K1 (0.35) | ROCK2OPRK1MAP4K1TBK1MET | |
| SCHEMBL20588769 | 0.87 | ROCK2 (0.34) | ROCK2OPRK1MAP4K1TBK1MET | |
| SCHEMBL20588354 | 0.87 | TBK1 (0.36) | ROCK2OPRK1MAP4K1TBK1MET | |
| SCHEMBL20587966 | 0.86 | TBK1 (0.35) | ROCK2OPRK1MAP4K1TBK1MET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3638669-A1 | SUBSTITUTED PYRROLOPYRIDINE-DERIVATIVES | Bayer Pharma Aktiengesellschaft (DE) | 2020-04-22 | — | — | EP | disclosed |
| WO-2018228920-A1 | SUBSTITUTED PYRROLOPYRIDINE-DERIVATIVES | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2018-12-20 | — | — | WO | disclosed |