Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSPB1 | P04792 | 3/20 | 0.45 |
| ▸ | HGFAC | Q04756 | 1/20 | 0.45 |
| ▸ | TTR | P02766 | 3/20 | 0.44 |
| ▸ | P2RX1 | P51575 | 2/20 | 0.44 |
| ▸ | TMPRSS4 | Q9NRS4 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | CES2 | O00748 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.41 |
| ▸ | PTGES | O14684 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28982636 | 0.84 | ALOX5 (0.57) | HSPB1HGFACTTRALDH1A1CES2 | |
| SCHEMBL19320489 | 0.81 | HGFAC (0.51) | HSPB1HGFACTTRALDH1A1CES2 | |
| SCHEMBL70054 | 0.80 | ALOX5 (0.58) | HSPB1HGFACTTRALDH1A1CES2 | |
| Ammonia Solution, Strong SCHEMBL27995845 | 0.77 | CES2 (0.58) | HSPB1HGFACTTRALDH1A1CES2 | |
| SCHEMBL27713384 | 0.76 | HSPB1 (0.63) | HSPB1TTRALDH1A1MEN1MAPT | |
| SCHEMBL29821424 | 0.76 | ALDH1A1 (0.55) | HSPB1TTRALDH1A1CES2MEN1 | |
| SCHEMBL29379815 | 0.76 | ALDH1A1 (0.55) | HSPB1TTRALDH1A1CES2MEN1 | |
| SCHEMBL1220299 | 0.76 | ALDH1A1 (0.55) | HSPB1TTRALDH1A1CES2MEN1 | |
| SCHEMBL427368 | 0.76 | ALDH1A1 (0.55) | HSPB1TTRALDH1A1CES2MEN1 | |
| SCHEMBL20591991 | 0.74 | HGFAC (0.50) | HSPB1HGFACTTRALDH1A1CES2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210255193-A1 | LYSINE REACTIVE PROBES AND USES THEREOF | THE SCRIPPS RESEARCH INSTITUTE | 2021-08-19 | — | — | US | disclosed |
| EP-3642630-A1 | LYSINE REACTIVE PROBES AND USES THEREOF | The Scripps Research Institute (US) | 2020-04-29 | — | — | EP | disclosed |
| US-20180372751-A1 | LYSINE REACTIVE PROBES AND USES THEREOF | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2018-12-27 | — | — | US | disclosed |
| WO-2018237334-A1 | LYSINE REACTIVE PROBES AND USES THEREOF | THE SCRIPPS RESEARCH INSTITUTE (US) | 2018-12-27 | — | — | WO | disclosed |