Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BMP4 | P12644 | 9/20 | 0.68 |
| ▸ | ACVR1 | Q04771 | 12/20 | 0.50 |
| ▸ | ACVR1B | P36896 | 11/20 | 0.50 |
| ▸ | ACVRL1 | P37023 | 10/20 | 0.50 |
| ▸ | BMPR1B | O00238 | 9/20 | 0.50 |
| ▸ | BMPR1A | P36894 | 9/20 | 0.50 |
| ▸ | KDR | P35968 | 7/20 | 0.50 |
| ▸ | TGFBR1 | P36897 | 6/20 | 0.50 |
| ▸ | PRKAB1 | Q9Y478 | 6/20 | 0.50 |
| ▸ | TGFBR2 | P37173 | 4/20 | 0.50 |
| ▸ | BMPR2 | Q13873 | 3/20 | 0.47 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.46 |
| ▸ | ACVR2A | P27037 | 1/20 | 0.46 |
| ▸ | ACVR2B | Q13705 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12779932 | 0.88 | BMP4 (0.62) | BMP4ACVR1ACVR1BACVRL1BMPR1B | |
| SCHEMBL2059669 | 0.85 | BMP4 (0.70) | BMP4ACVR1ACVR1BACVRL1BMPR1B | |
| SCHEMBL11953445 | 0.81 | BMP4 (1.00) | BMP4ACVR1ACVR1BACVRL1BMPR1B | |
| SCHEMBL24409662 | 0.80 | BMP4 (0.74) | BMP4ACVR1ACVR1BACVRL1BMPR1B | |
| SCHEMBL2059686 | 0.77 | BMP4 (1.00) | BMP4ACVR1ACVR1BACVRL1BMPR1B | |
| SCHEMBL27278122 | 0.74 | BMP4 (0.57) | BMP4ACVR1TGFBR1 | |
| SCHEMBL16111462 | 0.73 | BMP4 (0.85) | BMP4ACVR1ACVR1BACVRL1BMPR1B | |
| SCHEMBL12779933 | 0.71 | BMP4 (0.50) | BMP4ACVR1ACVR1BACVRL1BMPR1B | |
| SCHEMBL11953449 | 0.70 | BMP4 (1.00) | BMP4ACVR1ACVR1BACVRL1BMPR1B | |
| SCHEMBL17531593 | 0.69 | BMP4 (0.82) | BMP4ACVR1ACVR1BACVRL1BMPR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9045484-B2 | Inhibitors of the BMP signaling pathway | THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) | 2015-06-02 | — | — | US | disclosed |
| EP-2265603-B1 | INHIBITORS OF THE BMP SIGNALING PATHWAY | GEN HOSPITAL CORP (US) | 2014-05-07 | — | — | EP | disclosed |
| US-20140011805-A1 | INHIBITORS OF THE BMP SIGNALING PATHWAY | THE BRIGHAM AND WOMEN'S HOSPITAL, INC. | 2014-01-09 | — | — | US | disclosed |
| US-8507501-B2 | Inhibitors of the BMP signaling pathway | THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) | 2013-08-13 | — | — | US | disclosed |
| US-20110053930-A1 | INHIBITORS OF THE BMP SIGNALING PATHWAY | THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) | 2011-03-03 | — | — | US | disclosed |
| EP-2265603-A1 | INHIBITORS OF THE BMP SIGNALING PATHWAY | The General Hospital Corporation (US) | 2010-12-29 | — | — | EP | disclosed |
| WO-2009114180-A1 | INHIBITORS OF THE BMP SIGNALING PATHWAY | THE GENERAL HOSPITAL CORPORATION (US) | 2009-09-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110053930-A1 | INHIBITORS OF THE BMP SIGNALING PATHWAY | BMP1, BMP2K, BMP2 | BMP4 4/4885ACVR1 9/4885ACVR1B 11/4885 |
| US-20140011805-A1 | INHIBITORS OF THE BMP SIGNALING PATHWAY | BMP1, BMP2K, BMP2 | BMP4 4/4885ACVR1 9/4885ACVR1B 11/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.