SCHEMBL2059686

SCHEMBL2059686

c1ccc2c(-c3ccn4cc(-c5ccc(OCCN6CCCCC6)cc5)cnc34)ccnc2c1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
BMP4 P12644 4/20 1.00
ACVR1 Q04771 13/20 0.66
ACVRL1 P37023 9/20 0.66
BMPR1B O00238 8/20 0.66
BMPR1A P36894 5/20 0.66
ACVR1B P36896 5/20 0.66
KDR P35968 5/20 0.62
TGFBR1 P36897 3/20 0.62
PRKAB1 Q9Y478 3/20 0.62
FLT1 P17948 2/20 0.52
PRKAB2 O43741 1/20 0.52
LCK P06239 1/20 0.52
YES1 P07947 1/20 0.52
THRB P10828 1/20 0.52
SRC P12931 1/20 0.52
EIF2AK2 P19525 1/20 0.52
EPHA2 P29317 1/20 0.52
TGFBR2 P37173 1/20 0.52
PRKAG1 P54619 1/20 0.52
PRKAA2 P54646 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24787719 0.88 BMP4 (0.78) BMP4ACVR1ACVRL1BMPR1BBMPR1A
SCHEMBL11953448 0.85 BMP4 (1.00) BMP4ACVR1ACVRL1BMPR1BBMPR1A
SCHEMBL24409662 0.85 BMP4 (0.74) BMP4ACVR1ACVRL1BMPR1BBMPR1A
SCHEMBL2059669 0.80 BMP4 (0.70) BMP4ACVR1ACVRL1BMPR1BBMPR1A
SCHEMBL16025969 0.79 ACVR1 (1.00) BMP4ACVR1ACVRL1BMPR1BBMPR1A
SCHEMBL11953444 0.78 BMP4 (1.00) BMP4ACVR1ACVRL1BMPR1BBMPR1A
SCHEMBL12779932 0.77 BMP4 (0.62) BMP4ACVR1ACVRL1BMPR1BBMPR1A
SCHEMBL2059674 0.77 BMP4 (0.68) BMP4ACVR1ACVRL1BMPR1BBMPR1A
SCHEMBL29388057 0.77 PRKAB1 (1.00) BMP4ACVR1ACVRL1BMPR1BBMPR1A
SCHEMBL14671953 0.77 PRKAB1 (1.00) BMP4ACVR1ACVRL1BMPR1BBMPR1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230398118-A1 METHODS OF TREATING CARDIOVASCULAR-RELATED DISEASE KEROS THERAPEUTICS, INC. 2023-12-14 US disclosed
US-20230398118-A1 METHODS OF TREATING CARDIOVASCULAR-RELATED DISEASE KEROS THERAPEUTICS, INC. 2023-12-14 US disclosed
US-20230372390-A1 METHODS OF TREATING LYMPHOPENIA KEROS THERAPEUTICS, INC. 2023-11-23 US disclosed
US-20230372390-A1 METHODS OF TREATING LYMPHOPENIA KEROS THERAPEUTICS, INC. 2023-11-23 US disclosed
US-20220401445-A1 METHODS OF USING ALK2 INHIBITORS KEROS THERAPEUTICS, INC. 2022-12-22 US disclosed
US-10179111-B2 Treating soft tissue via controlled drug release University of Pittsburgh—of the Commonwealth System of Higher Education (US) 2019-01-15 US disclosed
US-20170014349-A1 TREATING SOFT TISSUE VIA CONTROLLED DRUG RELEASE UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) 2017-01-19 US disclosed
US-20170014349-A1 TREATING SOFT TISSUE VIA CONTROLLED DRUG RELEASE UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) 2017-01-19 US disclosed
US-20160263117-A1 COMPOSITIONS AND METHODS FOR CARDIOVASCULAR DISEASE NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR 2016-09-15 US disclosed
US-20160263117-A1 COMPOSITIONS AND METHODS FOR CARDIOVASCULAR DISEASE NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR 2016-09-15 US disclosed
US-20140011805-A1 INHIBITORS OF THE BMP SIGNALING PATHWAY THE BRIGHAM AND WOMEN'S HOSPITAL, INC. 2014-01-09 US disclosed
US-20140011805-A1 INHIBITORS OF THE BMP SIGNALING PATHWAY THE BRIGHAM AND WOMEN'S HOSPITAL, INC. 2014-01-09 US disclosed
US-8507501-B2 Inhibitors of the BMP signaling pathway THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) 2013-08-13 US disclosed
US-8507501-B2 Inhibitors of the BMP signaling pathway THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) 2013-08-13 US disclosed
US-8507501-B2 Inhibitors of the BMP signaling pathway THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) 2013-08-13 US disclosed
WO-2012100229-A2 COMPOSITIONS AND METHODS FOR CARDIOVASCULAR DISEASE THE GENERAL HOSPITAL CORPORATION (US) 2012-07-26 WO disclosed
US-20110053930-A1 INHIBITORS OF THE BMP SIGNALING PATHWAY THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) 2011-03-03 US disclosed
US-20110053930-A1 INHIBITORS OF THE BMP SIGNALING PATHWAY THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) 2011-03-03 US disclosed
US-20110053930-A1 INHIBITORS OF THE BMP SIGNALING PATHWAY THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) 2011-03-03 US disclosed
WO-2009114180-A1 INHIBITORS OF THE BMP SIGNALING PATHWAY THE GENERAL HOSPITAL CORPORATION (US) 2009-09-17 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160263117-A1 COMPOSITIONS AND METHODS FOR CARDIOVASCULAR DISEASE APOB, BMP1, LDLR BMP4 8/4885ACVR1 18/4885ACVRL1 24/4885
US-20220401445-A1 METHODS OF USING ALK2 INHIBITORS ALK, ACVR2A, ACVR1 BMP4 64/4885ACVR1 3/4885ACVRL1 6/4885
US-10179111-B2 Treating soft tissue via controlled drug release BMP2, BMP1, BMP6 BMP4 6/4885ACVR1 16/4885ACVRL1 25/4885
US-20110053930-A1 INHIBITORS OF THE BMP SIGNALING PATHWAY BMP1, BMP2K, BMP2 BMP4 4/4885ACVR1 9/4885ACVRL1 13/4885
US-20170014349-A1 TREATING SOFT TISSUE VIA CONTROLLED DRUG RELEASE BMP2, BMP1, BMP6 BMP4 6/4885ACVR1 16/4885ACVRL1 25/4885
US-20230398118-A1 METHODS OF TREATING CARDIOVASCULAR-RELATED DISEASE BMPR2, BMP1, BMP2 BMP4 7/4885ACVR1 13/4885ACVRL1 22/4885
US-20140011805-A1 INHIBITORS OF THE BMP SIGNALING PATHWAY BMP1, BMP2K, BMP2 BMP4 4/4885ACVR1 9/4885ACVRL1 13/4885
US-20230372390-A1 METHODS OF TREATING LYMPHOPENIA HAMP, BMPR2, BMP2 BMP4 17/4885ACVR1 16/4885ACVRL1 28/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.