Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.31 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.31 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.31 |
| ▸ | FLT4 | P35916 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26086878 | 0.75 | ALOX15 (0.44) | PLAUKMT2AOPRM1 | |
| SCHEMBL12002669 | 0.74 | OPRM1 (0.33) | PLAUCYP11B2OPRM1OPRL1 | |
| SCHEMBL14920534 | 0.73 | PLAU (0.44) | PLAUHTTKMT2AOPRM1OPRL1 | |
| SCHEMBL31360982 | 0.71 | KDM4E (0.38) | KMT2ACYP11B2 | |
| SCHEMBL16196153 | 0.70 | CYP11B2 (0.45) | HTTKMT2ACYP11B2 | |
| SCHEMBL9987096 | 0.70 | OPRL1 (0.49) | PLAUKMT2AOPRM1OPRL1 | |
| SCHEMBL16828742 | 0.68 | KDM4E (0.40) | PLAUHTTKMT2A | |
| SCHEMBL29442199 | 0.68 | KDM4E (0.40) | PLAUHTTKMT2A | |
| SCHEMBL27699345 | 0.67 | HTT (0.42) | HTTKMT2A | |
| SCHEMBL29284164 | 0.66 | KDM4E (0.43) | PLAUOPRM1OPRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019000236-A1 | 3-(1H-PYRAZOL-4-YL)PYRIDINE ALLOSTERIC MODULATORS OF M4 MUSCARINIC ACETYLCHOLINE RECEPTOR | MERCK SHARP & DOHME CORP. (US) | 2019-01-03 | — | — | WO | disclosed |