Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SOAT1 | P35610 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | PPM1B | O75688 | 1/20 | 0.35 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.35 |
| ▸ | PPP1CC | P36873 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | ACACB | O00763 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 3/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7666182 | 0.86 | MAPT (0.45) | ALDH1A1TSHRPPM1BPTPN1PPP1CC | |
| SCHEMBL2565618 | 0.82 | SOAT1 (0.61) | SOAT1ALDH1A1PPM1BPTPN1PPP1CC | |
| Hydrochloric Acid SCHEMBL27534001 | 0.80 | SOAT1 (0.58) | SOAT1ALDH1A1PPM1BPTPN1PPP1CC | |
| SCHEMBL6153652 | 0.77 | SOAT1 (0.54) | SOAT1ALDH1A1PPM1BPTPN1PPP1CC | |
| SCHEMBL7660003 | 0.76 | PPM1B (0.45) | ALDH1A1PPM1BPTPN1PPP1CCMAPT | |
| SCHEMBL11301518 | 0.76 | ALDH1A1 (0.47) | ALDH1A1TSHRPPM1BPTPN1PPP1CC | |
| SCHEMBL27549861 | 0.75 | ALDH1A1 (0.54) | SOAT1ALDH1A1TSHRMAPTGAA | |
| Hydrochloric Acid SCHEMBL28100636 | 0.75 | SOAT1 (0.52) | SOAT1ALDH1A1PPM1BPTPN1PPP1CC | |
| SCHEMBL72855 | 0.74 | MAPT (0.51) | ALDH1A1TSHRPPM1BPTPN1PPP1CC | |
| Hydrochloric Acid SCHEMBL27578586 | 0.74 | ALDH1A1 (0.53) | SOAT1ALDH1A1TSHRMAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3645516-A1 | HETEROARYLDIHYDROPYRIMIDINE DERIVATIVES AND METHODS OF TREATING HEPATITIS B INFECTIONS | Janssen Pharmaceutica NV (BE) | 2020-05-06 | — | — | EP | disclosed |
| WO-2019001420-A1 | HETEROARYLDIHYDROPYRIMIDINE DERIVATIVES AND METHODS OF TREATING HEPATITIS B INFECTIONS | JANSSEN PHARMACEUTICA NV (BE) | 2019-01-03 | — | — | WO | disclosed |