Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20599656 | 0.94 | FFAR3 (0.36) | NPSR1ALDH1A1SMN1; SMN2FFAR3 | |
| SCHEMBL7739592 | 0.73 | ALDH1A1 (0.45) | NPSR1ALDH1A1SMN1; SMN2FFAR3P2RX7 | |
| SCHEMBL14445398 | 0.72 | NPSR1 (0.50) | NPSR1ALDH1A1SMN1; SMN2FFAR3P2RX7 | |
| SCHEMBL17852 | 0.72 | NPSR1 (0.50) | NPSR1ALDH1A1SMN1; SMN2FFAR3P2RX7 | |
| SCHEMBL2481439 | 0.72 | FFAR3 (0.42) | NPSR1FFAR3 | |
| SCHEMBL8527912 | 0.72 | FFAR3 (0.42) | NPSR1ALDH1A1SMN1; SMN2FFAR3P2RX7 | |
| SCHEMBL4726410 | 0.71 | ALDH1A1 (0.40) | NPSR1ALDH1A1SMN1; SMN2FFAR3P2RX7 | |
| SCHEMBL21510462 | 0.70 | FFAR3 (0.40) | NPSR1ALDH1A1SMN1; SMN2FFAR3P2RX7 | |
| SCHEMBL7527879 | 0.70 | ALDH1A1 (0.42) | NPSR1ALDH1A1SMN1; SMN2FFAR3P2RX7 | |
| SCHEMBL1439569 | 0.70 | FFAR3 (0.40) | NPSR1ALDH1A1SMN1; SMN2FFAR3P2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3645516-A1 | HETEROARYLDIHYDROPYRIMIDINE DERIVATIVES AND METHODS OF TREATING HEPATITIS B INFECTIONS | Janssen Pharmaceutica NV (BE) | 2020-05-06 | — | — | EP | disclosed |
| WO-2019001420-A1 | HETEROARYLDIHYDROPYRIMIDINE DERIVATIVES AND METHODS OF TREATING HEPATITIS B INFECTIONS | JANSSEN PHARMACEUTICA NV (BE) | 2019-01-03 | — | — | WO | disclosed |