Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPHK1 | Q9NYA1 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.42 |
| ▸ | GMNN | O75496 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | THPO | P40225 | 1/20 | 0.42 |
| ▸ | MTOR | P42345 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | CETP | P11597 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | UBE2N | P61088 | 1/20 | 0.42 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.41 |
| ▸ | GPR84 | Q9NQS5 | 3/20 | 0.40 |
| ▸ | FDPS | P14324 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9575910 | 1.00 | SPHK1 (0.50) | SPHK1LMNAOPRM1CYP2D6GMNN | |
| Hydrochloric Acid SCHEMBL9794770 | 1.00 | SPHK1 (0.50) | SPHK1LMNAOPRM1CYP2D6GMNN | |
| SCHEMBL9575716 | 0.98 | SPHK1 (0.52) | SPHK1LMNAOPRM1CYP2D6GMNN | |
| SCHEMBL9575908 | 0.98 | SPHK1 (0.52) | SPHK1LMNAOPRM1CYP2D6GMNN | |
| Bromide SCHEMBL9575936 | 0.95 | SPHK1 (0.50) | SPHK1LMNAOPRM1CYP2D6GMNN | |
| Water SCHEMBL11079489 | 0.95 | SPHK1 (0.50) | SPHK1LMNAOPRM1CYP2D6GMNN | |
| Hydrochloric Acid SCHEMBL9575611 | 0.88 | FAAH (0.44) | LMNAGMNNPOLBBLMTP53 | |
| Bromide SCHEMBL9575619 | 0.84 | FAAH (0.44) | LMNAGMNNPOLBBLMTP53 | |
| Hydrochloric Acid SCHEMBL1831241 | 0.84 | SPHK1 (0.43) | SPHK1LMNAOPRM1TP53MAPT | |
| Hydrochloric Acid SCHEMBL9864879 | 0.84 | SPHK1 (0.43) | SPHK1LMNAOPRM1TP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2044926-B1 | ORAL COMPOSITION FOR DENTAL PURPOSES | NAT UNIV CORPORATION OKAYAMA UNIV (JP) | 2018-01-10 | — | — | EP | disclosed |
| US-8999298-B2 | Dental oral composition | NATIONAL UNIVERSITY CORPORATION OKAYAMA UNIVERSITY (JP) | 2015-04-07 | — | — | US | disclosed |
| US-8147807-B2 | Oral composition for dental purposes | NATIONAL UNIVERSITY CORPORATION OKAYAMA UNIVERSITY (JP) | 2012-04-03 | — | — | US | disclosed |
| US-20100330005-A1 | DENTAL ORAL COMPOSITION | KURARAY MEDICAL INC. (JP) | 2010-12-30 | — | — | US | disclosed |
| EP-2241304-A1 | DENTAL ORAL COMPOSITION | Kuraray Medical Inc. (JP) | 2010-10-20 | — | — | EP | disclosed |
| US-20100240714-A1 | ORAL COMPOSITION FOR DENTAL PURPOSES | NAT. UNI. CORP. OKAYAMA UNIVERSITY (JP) | 2010-09-23 | — | — | US | disclosed |
| EP-2044926-A1 | ORAL COMPOSITION FOR DENTAL PURPOSES | National University Corporation Okayama University (JP) | 2009-04-08 | — | — | EP | disclosed |
| US-6680286-B1 | CONTAINING AN ORGANIC POLYELECTROLYTE BUILDER, QUATERNARY AMMONIUM ACRYLIC POLYMERS, WHICH ARE ESPECIALLY USEFUL FOR WASHING CLOTHES | SANYO CHEMICAL INDUSTRIES, LTD. (JP) | 2004-01-20 | — | — | US | disclosed |
| EP-0371406-B1 | OXYALKYLATED QUATERNARY AMMONIUM COMPOUNDS, PROCESSES FOR PRODUCTION THEREOF, AND PLANT GROWTH REGULATING COMPOSITIONS CONTAINING SAID COMPOUNDS | DAI-ICHI KOGYO SEIYAKU CO., LTD. (JP) | 1993-08-04 | — | — | EP | disclosed |
| US-5076828-A | Immersing seeds into quaternary solution prior to planting | DAI-ICHI KOGYO SEIYAKU CO., LTD. (JP) | 1991-12-31 | — | — | US | disclosed |
| EP-0371406-A1 | Oxyalkylated quaternary ammonium compounds, processes for production thereof, and plant growth regulating compositions containing said compounds | DAI-ICHI KOGYO SEIYAKU CO., LTD. (JP) | 1990-06-06 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100330005-A1 | DENTAL ORAL COMPOSITION | TAS2R42, TAS2R43, PPM1G | SPHK1 1900/4885LMNA 4782/4885OPRM1 3340/4885 |
| US-20100240714-A1 | ORAL COMPOSITION FOR DENTAL PURPOSES | DDOST, PPM1G, PHOSPHO1 | SPHK1 851/4885LMNA 4854/4885OPRM1 3932/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.