Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 1/20 | 0.56 |
| ▸ | IDO1 | P14902 | 2/20 | 0.55 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.54 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.54 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 4/20 | 0.50 |
| ▸ | RAB9A | P51151 | 4/20 | 0.50 |
| ▸ | TP53 | P04637 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | GFER | P55789 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | NAMPT | P43490 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2565768 | 0.82 | HDAC3 (0.73) | HDAC3HDAC11HDAC8HDAC6NPC1 | |
| SCHEMBL14113538 | 0.82 | NPC1 (0.64) | JAK3IDO1HDAC3HDAC11HDAC8 | |
| SCHEMBL3303017 | 0.82 | NPC1 (0.64) | JAK3IDO1HDAC3HDAC11HDAC8 | |
| Benzene SCHEMBL28977956 | 0.79 | SMN1; SMN2 (0.70) | HDAC3HDAC11HDAC8HDAC6NPC1 | |
| SCHEMBL57554 | 0.79 | SMN1; SMN2 (0.70) | HDAC3HDAC11HDAC8HDAC6NPC1 | |
| SCHEMBL3541484 | 0.79 | NPC1 (0.53) | JAK3IDO1HDAC3HDAC11HDAC8 | |
| SCHEMBL3541478 | 0.79 | NPC1 (0.53) | JAK3IDO1HDAC3HDAC11HDAC8 | |
| SCHEMBL3543079 | 0.79 | HDAC8 (0.59) | HDAC3HDAC11HDAC8HDAC6NPC1 | |
| SCHEMBL22618106 | 0.78 | ATM (0.44) | JAK3IDO1HDAC3HDAC11HDAC8 | |
| SCHEMBL29739410 | 0.78 | ALDH1A1 (0.62) | RAB9ATP53SMN1; SMN2MEN1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2203415-B1 | (CYCLOPROPYL-PHENYL)-PHENYL-OXALAMIDES, METHOD FOR THEIR MANUFACTURE AND THEIR APPLICATION AS MEDICINES | SANOFI SA (FR) | 2016-10-26 | — | — | EP | disclosed |
| US-8148375-B2 | (Cyclopropylphenyl)phenyloxamides, method for the production thereof, and use of same as a medicament | SANOFI-AVENTIS (FR) | 2012-04-03 | — | — | US | disclosed |
| US-8148375-B2 | (Cyclopropylphenyl)phenyloxamides, method for the production thereof, and use of same as a medicament | SANOFI-AVENTIS (FR) | 2012-04-03 | — | — | US | disclosed |
| US-20100261644-A1 | (CYCLOPROPYLPHENYL)PHENYLOXAMIDES, METHOD FOR THE PRODUCTION THEREOF, AND USE OF SAME AS A MEDICAMENT | SANOFI-AVENTIS (FR) | 2010-10-14 | — | — | US | disclosed |
| US-20100261644-A1 | (CYCLOPROPYLPHENYL)PHENYLOXAMIDES, METHOD FOR THE PRODUCTION THEREOF, AND USE OF SAME AS A MEDICAMENT | SANOFI-AVENTIS (FR) | 2010-10-14 | — | — | US | disclosed |
| CN-101796018-A | (cyclopropylphenyl) phenyloxamides, their production and their use as medicaments | SANOFI AVENTIS | 2010-08-04 | — | — | CN | disclosed |
| CN-101796018-A | (cyclopropylphenyl) phenyloxamides, their production and their use as medicaments | SANOFI AVENTIS | 2010-08-04 | — | — | CN | disclosed |
| EP-2203415-A1 | (CYCLOPROPYL-PHENYL)-PHENYL-OXALAMIDES, METHOD FOR THE PRODUCTION THEREOF, AND USE OF SAME AS A MEDICAMENT | Sanofi-Aventis (FR) | 2010-07-07 | — | — | EP | disclosed |
| EP-2203415-A1 | (CYCLOPROPYL-PHENYL)-PHENYL-OXALAMIDES, METHOD FOR THE PRODUCTION THEREOF, AND USE OF SAME AS A MEDICAMENT | Sanofi-Aventis (FR) | 2010-07-07 | — | — | EP | disclosed |
| WO-2009039942-A1 | (CYCLOPROPYL-PHENYL)-PHENYL-OXALAMIDES, METHOD FOR THE PRODUCTION THEREOF, AND USE OF SAME AS A MEDICAMENT | SANOFI-AVENTIS (FR) | 2009-04-02 | — | — | WO | disclosed |
| WO-2009039942-A1 | (CYCLOPROPYL-PHENYL)-PHENYL-OXALAMIDES, METHOD FOR THE PRODUCTION THEREOF, AND USE OF SAME AS A MEDICAMENT | SANOFI-AVENTIS (FR) | 2009-04-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100261644-A1 | (CYCLOPROPYLPHENYL)PHENYLOXAMIDES, METHOD FOR THE PRODUCTION THEREOF, AND USE OF SAME AS A MEDICAMENT | PPOX, OAT, PNPO | JAK3 2607/4885IDO1 416/4885HDAC3 2753/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.