Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2061229 | 0.81 | MAPT (0.37) | MAPTALDH1A1KMT2AMEN1CYP3A4 | |
| SCHEMBL2060712 | 0.81 | — | — | |
| SCHEMBL879717 | 0.69 | MAPT (0.44) | MAPTALDH1A1KDM4EKMT2AMEN1 | |
| SCHEMBL2060737 | 0.69 | KCNH2 (0.51) | MAPTALDH1A1KDM4EPOLB | |
| SCHEMBL5010661 | 0.67 | GAA (0.41) | MAPTALDH1A1KMT2AMEN1CYP3A4 | |
| SCHEMBL1169394 | 0.66 | MAPT (0.52) | MAPTALDH1A1KMT2AMEN1CYP3A4 | |
| SCHEMBL5391850 | 0.65 | MAPT (0.45) | MAPTALDH1A1KMT2AMEN1CYP3A4 | |
| SCHEMBL233475 | 0.65 | MAPT (0.51) | MAPTALDH1A1KMT2AMEN1CYP3A4 | |
| SCHEMBL2061228 | 0.64 | MAPT (0.38) | MAPTALDH1A1KDM4EKMT2AMEN1 | |
| SCHEMBL31414482 | 0.64 | CA1 (0.46) | MAPTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8148422-B2 | Sulfonamides as TRPM8 modulators | JANSSEN PHARMACEUTICA, NV (BE) | 2012-04-03 | — | — | US | disclosed |