Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | TSHR | P16473 | 3/20 | 0.53 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 3/20 | 0.51 |
| ▸ | THRB | P10828 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.50 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | ERN1 | O75460 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6562050 | 0.86 | GPR35 (0.53) | ALDH1A1TSHRGPR35HPGDSMN1; SMN2 | |
| SCHEMBL10232248 | 0.84 | TDP1 (0.36) | ALDH1A1TSHRGPR35HPGDSMN1; SMN2 | |
| SCHEMBL27708625 | 0.81 | GRIK1 (0.51) | ALDH1A1TSHRGPR35HPGDSMN1; SMN2 | |
| SCHEMBL11703644 | 0.80 | IDO1 (0.57) | ALDH1A1TSHRGPR35HPGDSMN1; SMN2 | |
| SCHEMBL13253426 | 0.79 | TDP1 (0.56) | ALDH1A1TSHRTDP1NPSR1MAPT | |
| SCHEMBL1744862 | 0.79 | ALDH1A1 (0.53) | ALDH1A1TSHRMAPK1GAATDP1 | |
| SCHEMBL5786188 | 0.78 | KMT2A (0.56) | ALDH1A1TSHRSMN1; SMN2TDP1MEN1 | |
| SCHEMBL6677996 | 0.77 | GAA (0.57) | ALDH1A1TSHRGPR35HPGDSMN1; SMN2 | |
| SCHEMBL10913298 | 0.76 | HSD17B10 (0.56) | ALDH1A1HPGDSMN1; SMN2MAPK1GAA | |
| SCHEMBL7838979 | 0.76 | ALDH1A1 (0.55) | ALDH1A1TSHRSMN1; SMN2GAATHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1304994-B1 | PYRROLYL-SUBSTITUTED NITROPHENOLS USED AS DIRECT COLORANTS | HENKEL KGAA (DE) | 2004-10-20 | — | — | EP | claimed |
| EP-2684874-B1 | Fused bicyclic derivatives of 2,4-diaminopyrimidine as alk and C-met inhibitors | CEPHALON INC (US) | 2017-05-17 | — | — | EP | disclosed |
| EP-2222647-B1 | FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND C-MET INHIBITORS | CEPHALON INC (US) | 2015-08-05 | — | — | EP | disclosed |
| EP-2684874-A1 | Fused bicyclic derivatives of 2,4-diaminopyrimidine as alk and C-met inhibitors | Cephalon, Inc. (US) | 2014-01-15 | — | — | EP | disclosed |
| US-8552186-B2 | Fused bicyclic derivatives of 2,4-diaminopyrimidine as ALK and c-MET inhibitors | CEPHALON, INC. (US) | 2013-10-08 | — | — | US | disclosed |
| US-20120165519-A1 | Fused Bicyclic Derivatives of 2,4-Diaminopyrimidine as ALK and c-MET Inhibitors | CEPHALON, INC. (US) | 2012-06-28 | — | — | US | disclosed |
| US-8148391-B2 | Fused bicyclic derivatives of 2,4-diaminopyrimidine as ALK and c-Met inhibitors | CEPHALON, INC. (US) | 2012-04-03 | — | — | US | disclosed |
| US-8148391-B2 | Fused bicyclic derivatives of 2,4-diaminopyrimidine as ALK and c-Met inhibitors | CEPHALON, INC. (US) | 2012-04-03 | — | — | US | disclosed |
| EP-2222647-A1 | FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND C-MET INHIBITORS | Cephalon, Inc. (US) | 2010-09-01 | — | — | EP | disclosed |
| US-20090221555-A1 | FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND c-MET INHIBITORS | CEPHALON, INC. (US) | 2009-09-03 | — | — | US | disclosed |
| EP-1304994-B1 | PYRROLYL-SUBSTITUTED NITROPHENOLS USED AS DIRECT COLORANTS | HENKEL KGAA (DE) | 2004-10-20 | — | — | EP | disclosed |
| EP-0775689-B9 | NOVEL AMINE DERIVATIVE, PROCESS FOR PRODUCING THE SAME, AND USE THEREOF AS ANTIARRHYTHMIC | C & C RES LABS (KR) | 2004-09-15 | — | — | EP | disclosed |
| CN-1134410-C | Amine derivatives, process for their preparation and their use as antiarrhythmic agents | �й�ʯ����������ʯ�ͻ����������ι� | 2004-01-14 | — | — | CN | disclosed |
| EP-0775689-B1 | NOVEL AMINE DERIVATIVE, PROCESS FOR PRODUCING THE SAME, AND USE THEREOF AS ANTIARRHYTHMIC | C & C RES LABS (KR) | 2003-09-03 | — | — | EP | disclosed |
| EP-1304994-A1 | PYRROLYL-SUBSTITUTED NITROPHENOLS USED AS DIRECT COLORANTS | Henkel Kommanditgesellschaft auf Aktien (DE) | 2003-05-02 | — | — | EP | disclosed |
| WO-2002009661-A1 | PYRROLYL-SUBSTITUTED NITROPHENOLS USED AS DIRECT COLORANTS | HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) | 2002-02-07 | — | — | WO | disclosed |
| US-6057358-A | POTASSIUM CHANNEL BLOCKING ANTIARRHYTHMIC DRUGS WITH LESS SIDE EFFECTS | C&C RESEARCH LABS. (KR) | 2000-05-02 | — | — | US | disclosed |
| CN-1169141-A | Novel amine derivatives, process for their preparation and their use as antiarrhythmic agents | C & C RESEARCH LABS (KR) | 1997-12-31 | — | — | CN | disclosed |
| EP-0775689-A1 | NOVEL AMINE DERIVATIVE, PROCESS FOR PRODUCING THE SAME, AND USE THEREOF AS ANTIARRHYTHMIC | C & C RESEARCH LABS. (KR) | 1997-05-28 | — | — | EP | disclosed |
| US-4035495-A | HYPERTENSIVE AGENTS, CNS DEPRESSANT | AYERST MCKENNA AND HARRISON LTD. (CA) | 1977-07-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090221555-A1 | FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND c-MET INHIBITORS | ALK, MET, RET | ALDH1A1 77/4885TSHR 1728/4885GPR35 2460/4885 |
| US-20120165519-A1 | Fused Bicyclic Derivatives of 2,4-Diaminopyrimidine as ALK and c-MET Inhibitors | ALK, MET, RET | ALDH1A1 77/4885TSHR 1728/4885GPR35 2460/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.