Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2RL1 | P55085 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | EGFR | P00533 | 1/20 | 0.47 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | BCHE | P06276 | 1/20 | 0.45 |
| ▸ | ACHE | P22303 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | BMP1 | P13497 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8780852 | 0.86 | FKBP1A (0.53) | ALDH1A1KMT2AEGFRFKBP1AMAPT | |
| SCHEMBL2333789 | 0.85 | ALDH1A1 (0.51) | ALDH1A1EGFRFKBP1ALMNAL3MBTL1 | |
| SCHEMBL6803332 | 0.83 | ALDH1A1 (0.55) | ALDH1A1KMT2AEGFRFKBP1ALMNA | |
| SCHEMBL8710128 | 0.80 | ALDH1A1 (0.51) | ALDH1A1EGFRFKBP1ALMNAMAPT | |
| SCHEMBL3685139 | 0.79 | PSMD10 (0.48) | ALDH1A1KMT2AFKBP1ALMNAPKM | |
| SCHEMBL18934371 | 0.77 | ALDH1A1 (0.47) | ALDH1A1KMT2AFKBP1ALMNA | |
| SCHEMBL2567795 | 0.77 | ALDH1A1 (0.47) | ALDH1A1KMT2AFKBP1ALMNA | |
| SCHEMBL6530245 | 0.77 | ALDH1A1 (0.55) | ALDH1A1EGFRLMNAMAPTBCHE | |
| SCHEMBL20221728 | 0.76 | ALDH1A1 (0.53) | F2RL1ALDH1A1KMT2ALMNAL3MBTL1 | |
| SCHEMBL13508559 | 0.76 | IDO1 (0.48) | ALDH1A1KMT2ALMNAL3MBTL1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118515685-A | Synthesis of halichondrin | 哈佛大学的校长及成员们 | 2024-08-20 | — | — | CN | disclosed |
| CN-111433211-B | Synthesis of halichondrin | 哈佛大学的校长及成员们 | 2024-05-07 | — | — | CN | disclosed |
| US-20230128195-A1 | SYNTHESIS OF HALICHONDRINS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2023-04-27 | — | — | US | disclosed |
| EP-4169924-A2 | SYNTHESIS OF HALICHONDRINS | President And Fellows Of Harvard College (US) | 2023-04-26 | — | — | EP | disclosed |
| US-11548898-B2 | Synthesis of halichondrins | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2023-01-10 | — | — | US | disclosed |
| EP-3649135-B1 | SYNTHESIS OF HALICHONDRINS | HARVARD COLLEGE (US) | 2022-12-28 | — | — | EP | disclosed |
| US-20210230177-A1 | SYNTHESIS OF HALICHONDRINS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2021-07-29 | — | — | US | disclosed |
| CN-111433211-A | Synthesis of halichondrin | 哈佛大学的校长及成员们 | 2020-07-17 | — | — | CN | disclosed |
| EP-3649135-A1 | SYNTHESIS OF HALICHONDRINS | President and Fellows of Harvard College (US) | 2020-05-13 | — | — | EP | disclosed |
| WO-2019010363-A1 | SYNTHESIS OF HALICHONDRINS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2019-01-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11548898-B2 | Synthesis of halichondrins | H1-3, NISCH, H1-5 | F2RL1 4323/4885ALDH1A1 1798/4885KMT2A 91/4885 |
| US-20230128195-A1 | SYNTHESIS OF HALICHONDRINS | H1-3, NISCH, HDAC11 | F2RL1 4305/4885ALDH1A1 1842/4885KMT2A 90/4885 |
| US-20210230177-A1 | SYNTHESIS OF HALICHONDRINS | H1-3, NISCH, HDAC11 | F2RL1 4314/4885ALDH1A1 1776/4885KMT2A 72/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.