Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.51 |
| ▸ | BCHE | P06276 | 1/20 | 0.51 |
| ▸ | ACHE | P22303 | 1/20 | 0.51 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | EGFR | P00533 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.43 |
| ▸ | CNR1 | P21554 | 1/20 | 0.43 |
| ▸ | CNR2 | P34972 | 1/20 | 0.43 |
| ▸ | CYP24A1 | Q07973 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8780852 | 0.96 | FKBP1A (0.53) | ALDH1A1BCHEACHEFKBP1AHTT | |
| SCHEMBL6803332 | 0.90 | ALDH1A1 (0.55) | ALDH1A1BCHEACHEFKBP1AHTT | |
| SCHEMBL18934371 | 0.87 | ALDH1A1 (0.47) | ALDH1A1FKBP1ASMN1; SMN2CNR2LMNA | |
| SCHEMBL2567795 | 0.87 | ALDH1A1 (0.47) | ALDH1A1FKBP1ASMN1; SMN2CNR2LMNA | |
| SCHEMBL8710128 | 0.86 | ALDH1A1 (0.51) | ALDH1A1BCHEACHEFKBP1AHTT | |
| SCHEMBL14339870 | 0.86 | CA2 (0.43) | ALDH1A1FKBP1AHTTSMN1; SMN2MAPT | |
| SCHEMBL8498573 | 0.86 | CA2 (0.51) | ALDH1A1HTTSMN1; SMN2CNR2LMNA | |
| SCHEMBL20610741 | 0.85 | F2RL1 (0.51) | ALDH1A1BCHEACHEFKBP1AHTT | |
| SCHEMBL8499603 | 0.84 | CA2 (0.53) | ALDH1A1ACHEHTTEGFRSMN1; SMN2 | |
| SCHEMBL13649253 | 0.84 | ENPP1 (0.52) | ALDH1A1FKBP1AHTTSMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 54 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190241528-A1 | SODIUM CHANNEL BLOCKERS | PARION SCIENCES, INC. (US) | 2019-08-08 | — | — | US | disclosed |
| US-10167266-B2 | Sodium channel blockers | PARION SCIENCES, INC. (US) | 2019-01-01 | — | — | US | disclosed |
| US-20170267650-A1 | SODIUM CHANNEL BLOCKERS | PARION SCIENCES, INC. (US) | 2017-09-21 | — | — | US | disclosed |
| US-20150376146-A1 | SODIUM CHANNEL BLOCKERS | PARION SCIENCES, INC. (US) | 2015-12-31 | — | — | US | disclosed |
| US-8846688-B2 | Sodium channel blockers | PARION SCIENCES, INC. (US) | 2014-09-30 | — | — | US | disclosed |
| US-20140179625-A1 | SODIUM CHANNEL BLOCKERS | PARION SCIENCES, INC. (US) | 2014-06-26 | — | — | US | disclosed |
| US-20130012692-A1 | SODIUM CHANNEL BLOCKERS | PARION SCIENCES, INC. (US) | 2013-01-10 | — | — | US | disclosed |
| US-8227474-B2 | Sodium channel blockers | PARION SCIENCES, INC. (US) | 2012-07-24 | — | — | US | disclosed |
| US-8198286-B2 | Sodium channel blockers | PARION SCIENCES, INC. (US) | 2012-06-12 | — | — | US | disclosed |
| EP-1485360-B1 | SODIUM CHANNEL BLOCKERS | PARION SCIENCES INC (US) | 2011-08-17 | — | — | EP | disclosed |
| US-20040198745-A1 | Sodium channel blockers | PARION SCIENCES, INC. (US) | 2004-10-07 | — | — | US | disclosed |
| US-20040198746-A1 | Sodium channel blockers | PARION SCIENCES, INC. (US) | 2004-10-07 | — | — | US | disclosed |
| US-20040198749-A1 | Broncholdilator agents; hydration of mucous membranes; respiratory system disorders | PARION SCIENCES, INC. | 2004-10-07 | — | — | US | disclosed |
| US-20040198748-A1 | Antihistamines; bronchodilators; antiinflammatory agents; inflammatory bowel disorders | PARION SCIENCES, INC. | 2004-10-07 | — | — | US | disclosed |
| US-20040198747-A1 | Sodium channel blockers | PARION SCIENCES, INC. (US) | 2004-10-07 | — | — | US | disclosed |
| US-20040198744-A1 | Methods of using phenolic guanidine sodium channel blockers | PARION SCIENCES, INC. | 2004-10-07 | — | — | US | disclosed |
| US-20030199456-A1 | Treating diseases characterized by too little liquid on mucosal surfaces using a\"topical\" sodium channel blocker designed to increased potency, reduced mucosal absorption, and slow dissociation; 2,6-diaminopyrazine derivatives | CYFI, INC. (US) | 2003-10-23 | — | — | US | disclosed |
| US-20030195160-A1 | Sodium channel blockers | CYFI, INC. | 2003-10-16 | — | — | US | disclosed |
| WO-2003070182-A2 | SODIUM CHANNEL BLOCKERS | JOHNSON MICHAEL R (US) | 2003-08-28 | — | — | WO | disclosed |
| WO-2003070184-A2 | SODIUM CHANNEL BLOCKERS | JOHNSON MICHAEL R (US) | 2003-08-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (14 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170267650-A1 | SODIUM CHANNEL BLOCKERS | HCN4, SCN2B, SCN5A | ALDH1A1 1210/4885BCHE 3168/4885ACHE 925/4885 |
| US-10167266-B2 | Sodium channel blockers | SCNN1B, SCNN1A, SCNN1G | ALDH1A1 941/4885BCHE 3819/4885ACHE 1845/4885 |
| US-20150376146-A1 | SODIUM CHANNEL BLOCKERS | HCN4, SCN2B, SCN5A | ALDH1A1 1210/4885BCHE 3168/4885ACHE 925/4885 |
| US-20030195160-A1 | Sodium channel blockers | HCN4, SCN2B, SCN5A | ALDH1A1 1348/4885BCHE 2899/4885ACHE 828/4885 |
| US-20040198747-A1 | Sodium channel blockers | HCN4, SCN2B, SCN5A | ALDH1A1 1348/4885BCHE 2899/4885ACHE 828/4885 |
| US-20040198745-A1 | Sodium channel blockers | SCN2B, SCN4A, SCN1B | ALDH1A1 1034/4885BCHE 3782/4885ACHE 1789/4885 |
| US-20040198744-A1 | Methods of using phenolic guanidine sodium channel blockers | KCNH2, KCNH3, KCNJ1 | ALDH1A1 1078/4885BCHE 2141/4885ACHE 336/4885 |
| US-20140179625-A1 | SODIUM CHANNEL BLOCKERS | HCN4, SCN2B, SCN5A | ALDH1A1 1210/4885BCHE 3168/4885ACHE 925/4885 |
| US-20040198746-A1 | Sodium channel blockers | HCN4, SCN2B, SCN5A | ALDH1A1 1348/4885BCHE 2899/4885ACHE 828/4885 |
| US-20040198749-A1 | Broncholdilator agents; hydration of mucous membranes; respiratory system disorders | AQP1, TRPV1, AQP3 | ALDH1A1 1642/4885BCHE 1740/4885ACHE 1380/4885 |
| US-20130012692-A1 | SODIUM CHANNEL BLOCKERS | HCN4, SCN2B, SCN5A | ALDH1A1 1210/4885BCHE 3168/4885ACHE 925/4885 |
| US-20030199456-A1 | Treating diseases characterized by too little liquid on mucosal surfaces using a\"topical\" sodium channel blocker designed to increased potency, reduced mucosal absorption, and slow dissociation; 2,6-diaminopyrazine derivatives | SCNN1B, KCNN2, KCNN1 | ALDH1A1 1618/4885BCHE 3794/4885ACHE 1968/4885 |
| US-20040198748-A1 | Antihistamines; bronchodilators; antiinflammatory agents; inflammatory bowel disorders | HRH4, HRH2, HRH1 | ALDH1A1 651/4885BCHE 1121/4885ACHE 748/4885 |
| US-20190241528-A1 | SODIUM CHANNEL BLOCKERS | HCN4, SCN2B, SCN5A | ALDH1A1 1210/4885BCHE 3168/4885ACHE 925/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.