Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.87 |
| ▸ | LMNA | P02545 | 1/20 | 0.87 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.81 |
| ▸ | HPGD | P15428 | 2/20 | 0.81 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.81 |
| ▸ | HTT | P42858 | 1/20 | 0.81 |
| ▸ | USP2 | O75604 | 2/20 | 0.76 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.76 |
| ▸ | MEN1 | O00255 | 3/20 | 0.74 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.73 |
| ▸ | POLB | P06746 | 1/20 | 0.73 |
| ▸ | GAA | P10253 | 1/20 | 0.73 |
| ▸ | MAPT | P10636 | 1/20 | 0.73 |
| ▸ | ALPG | P10696 | 1/20 | 0.73 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.73 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.73 |
| ▸ | RECQL | P46063 | 1/20 | 0.73 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.73 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL647000 | 0.85 | ALDH1A1 (1.00) | SMN1; SMN2LMNAALDH1A1HPGDNPSR1 | |
| SCHEMBL3866653 | 0.78 | ALDH1A1 (0.58) | SMN1; SMN2LMNAALDH1A1HPGDNPSR1 | |
| SCHEMBL3868831 | 0.76 | GAA (0.91) | LMNAALDH1A1NPSR1HTTKDM4E | |
| SCHEMBL12830660 | 0.71 | KMT2A (0.81) | SMN1; SMN2LMNAALDH1A1HTTUSP2 | |
| SCHEMBL28732507 | 0.71 | IGSF11 (1.00) | SMN1; SMN2LMNAALDH1A1HPGDKMT2A | |
| SCHEMBL12870002 | 0.70 | USP2 (0.70) | SMN1; SMN2LMNAALDH1A1HPGDNPSR1 | |
| SCHEMBL12961753 | 0.70 | HPGD (0.77) | SMN1; SMN2LMNAALDH1A1HPGDNPSR1 | |
| SCHEMBL16896085 | 0.69 | KMT2A (1.00) | LMNAALDH1A1HPGDKMT2AMEN1 | |
| SCHEMBL2722164 | 0.68 | POLB (0.82) | LMNAALDH1A1HPGDNPSR1HTT | |
| SCHEMBL28672670 | 0.68 | HPGD (0.69) | SMN1; SMN2ALDH1A1HPGDNPSR1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220204484-A1 | CHEMICAL INHIBITION OF THE E3 LIGASE SUBUNIT FBXO7 CONFERS NEUROPROTECTION AND ANTI-INFLAMMATORY ACTIVITY BY STABILIZING MITOCHONDRIA | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2022-06-30 | — | — | US | disclosed |
| US-11242339-B2 | Chemical inhibition of the E3 ligase subunit FBXO7 confers neuroprotection and anti-inflammatory activity by stabilizing mitochondria | University of Pittsburgh—of the Commonwealth System of Higher Education (US) | 2022-02-08 | — | — | US | disclosed |
| US-20200216426-A1 | CHEMICAL INHIBITION OF THE E3 LIGASE SUBUNIT FBXO7 CONFERS NEUROPROTECTION AND ANTI-INFLAMMATORY ACTIVITY BY STABILIZING MITOCHONDRIA | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2020-07-09 | — | — | US | disclosed |
| WO-2019005685-A1 | CHEMICAL INHIBITION OF THE E3 LIGASE SUBUNIT FBX07 CONFERS NEUROPROTECTION AND ANTI-INFLAMMATORY ACTIVITY BY STABILIZING MITOCHONDRIA | UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2019-01-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200216426-A1 | CHEMICAL INHIBITION OF THE E3 LIGASE SUBUNIT FBXO7 CONFERS NEUROPROTECTION AND ANTI-INFLAMMATORY ACTIVITY BY STABILIZING MITOCHONDRIA | FBXL19, MAVS, XIAP | SMN1; SMN2 318/4885LMNA 3236/4885ALDH1A1 1963/4885 |
| US-20220204484-A1 | CHEMICAL INHIBITION OF THE E3 LIGASE SUBUNIT FBXO7 CONFERS NEUROPROTECTION AND ANTI-INFLAMMATORY ACTIVITY BY STABILIZING MITOCHONDRIA | FBXL19, MAVS, XIAP | SMN1; SMN2 318/4885LMNA 3236/4885ALDH1A1 1963/4885 |
| US-11242339-B2 | Chemical inhibition of the E3 ligase subunit FBXO7 confers neuroprotection and anti-inflammatory activity by stabilizing mitochondria | FBXL19, MAVS, XIAP | SMN1; SMN2 318/4885LMNA 3236/4885ALDH1A1 1963/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.