Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.81 |
| ▸ | USP2 | O75604 | 2/20 | 0.69 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.69 |
| ▸ | TSHR | P16473 | 3/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.64 |
| ▸ | LMNA | P02545 | 1/20 | 0.64 |
| ▸ | CA2 | P00918 | 1/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.63 |
| ▸ | RAB9A | P51151 | 1/20 | 0.63 |
| ▸ | MEN1 | O00255 | 1/20 | 0.61 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | ATM | Q13315 | 1/20 | 0.56 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12870002 | 0.75 | USP2 (0.70) | KMT2AUSP2TSHRSMN1; SMN2LMNA | |
| SCHEMBL14428687 | 0.75 | KMT2A (0.70) | KMT2AUSP2KDM4ETSHRSMN1; SMN2 | |
| SCHEMBL8289713 | 0.71 | ALDH1A1 (0.71) | KMT2AUSP2KDM4ETSHRSMN1; SMN2 | |
| SCHEMBL20614872 | 0.71 | SMN1; SMN2 (0.87) | KMT2AUSP2KDM4ESMN1; SMN2LMNA | |
| SCHEMBL3871973 | 0.69 | CA2 (0.76) | KMT2AUSP2KDM4ETSHRSMN1; SMN2 | |
| SCHEMBL13977453 | 0.67 | CTSD (0.78) | KMT2AUSP2KDM4ETSHRALDH1A1 | |
| SCHEMBL3873519 | 0.67 | CA2 (0.77) | TSHRSMN1; SMN2LMNACA2ALDH1A1 | |
| SCHEMBL3867743 | 0.66 | KMT2A (0.59) | KMT2AUSP2KDM4ETSHRSMN1; SMN2 | |
| SCHEMBL2354757 | 0.65 | KMT2A (0.58) | KMT2AUSP2KDM4ETSHRLMNA | |
| SCHEMBL5152197 | 0.65 | TP53 (0.65) | KMT2AUSP2KDM4ETSHRSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2289504-A2 | SIRT1 modulators for manipulating cell/organism lifespan/stress response | President and Fellows of Harvard College (US) | 2011-03-02 | — | — | EP | disclosed |
| US-7544497-B2 | Compositions for manipulating the lifespan and stress response of cells and organisms | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2009-06-09 | — | — | US | disclosed |