Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 10/20 | 0.39 |
| ▸ | RAB9A | P51151 | 10/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.39 |
| ▸ | RELA | Q04206 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.37 |
| ▸ | AR | P10275 | 2/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20622490 | 0.84 | TDP2 (0.43) | KDM4ECYP1A2NISCHSYKMAPKAPK2 | |
| SCHEMBL26040396 | 0.79 | NPC1 (0.51) | NPC1RAB9AKDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL20642575 | 0.77 | TDP1 (0.43) | NPC1RAB9AKDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL18845434 | 0.75 | NPC1 (0.45) | NPC1RAB9AKDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL15397046 | 0.74 | NPC1 (0.59) | NPC1RAB9AKDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL19772294 | 0.72 | NPC1 (0.42) | NPC1RAB9AKDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL17343466 | 0.72 | NPC1 (0.44) | NPC1RAB9AKDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL17343363 | 0.72 | NPC1 (0.47) | NPC1RAB9AKDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL18717161 | 0.71 | NPC1 (0.54) | NPC1RAB9AKDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL31038194 | 0.71 | NPC1 (0.54) | NPC1RAB9AKDM4ESMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190002478-A1 | HETEROCYCLIC COMPOUNDS AS RSV INHIBITORS | ENANTA PHARMACEUTICALS, INC. | 2019-01-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190002478-A1 | HETEROCYCLIC COMPOUNDS AS RSV INHIBITORS | SIRT1, FURIN, SIRT5 | NPC1 250/4885RAB9A 575/4885KDM4E 1342/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.