SCHEMBL20619418

SCHEMBL20619418

Cc1ccccc1-c1ccc2c(c1)c1cc(-c3ccccc3C)ccc1n2-c1cc(-c2cccnc2-c2ccccc2)cc(-n2c3ccc(-c4ccccc4C)cc3c3cc(-c4ccccc4C)ccc32)c1C#N

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PTGS1 P23219 1/20 0.37
PTGS2 P35354 1/20 0.37
SQOR Q9Y6N5 3/20 0.37
FEN1 P39748 1/20 0.36
PIP4K2A P48426 2/20 0.35
ALDH1A1 P00352 5/20 0.34
AR P10275 1/20 0.34
TDP1 Q9NUW8 1/20 0.34
L3MBTL1 Q9Y468 1/20 0.34
HSD17B10 Q99714 3/20 0.34
CYP1A2 P05177 3/20 0.34
CYP3A4 P08684 3/20 0.34
CYP2D6 P10635 3/20 0.34
CYP2C19 P33261 3/20 0.34
CLK4 Q9HAZ1 3/20 0.34
CYP2C9 P11712 2/20 0.34
HTT P42858 2/20 0.34
LMNA P02545 2/20 0.34
KDM4E B2RXH2 1/20 0.34
TP53 P04637 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20619416 0.97 SQOR (0.37) PTGS1PTGS2SQORFEN1PIP4K2A
SCHEMBL23912047 0.94 SQOR (0.35) PTGS1PTGS2SQORFEN1PIP4K2A
SCHEMBL20619412 0.92 PTGS1 (0.37) PTGS1PTGS2SQORFEN1PIP4K2A
SCHEMBL23912051 0.91 SQOR (0.38) PTGS1PTGS2SQORPIP4K2AALDH1A1
SCHEMBL20619476 0.91 PTGS1 (0.38) PTGS1PTGS2FEN1ALDH1A1HSD17B10
SCHEMBL23912104 0.90 ADORA1 (0.40) PTGS1PTGS2SQORFEN1ALDH1A1
SCHEMBL23912102 0.90 FEN1 (0.35) PTGS1PTGS2SQORFEN1TDP1
SCHEMBL20619692 0.89 ADORA1 (0.38) PTGS1PTGS2FEN1ALDH1A1TDP1
SCHEMBL20619452 0.87 TDO2 (0.38) PTGS1PTGS2FEN1ALDH1A1HSD17B10
SCHEMBL20619413 0.86 ADORA1 (0.37) PTGS1PTGS2SQORFEN1PIP4K2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3645522-B1 ORGANIC MOLECULES, IN PARTICULAR FOR USE IN OPTOELECTRONIC DEVICES CYNORA GMBH (DE) 2021-10-13 EP disclosed
WO-2019002174-A1 ORGANIC MOLECULES, IN PARTICULAR FOR USE IN OPTOELECTRONIC DEVICES CYNORA GMBH (DE) 2019-01-03 WO disclosed