Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 2/20 | 0.39 |
| ▸ | CCR1 | P32246 | 1/20 | 0.39 |
| ▸ | CCR5 | P51681 | 1/20 | 0.39 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | ACAT1 | P24752 | 1/20 | 0.39 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.33 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | DRD4 | P21917 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.32 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19413239 | 0.89 | EPHX1 (0.33) | CCR2CCR1CCR5CXCR4MAPT | |
| SCHEMBL20417207 | 0.83 | RIPK1 (0.47) | CCR2RIPK1DRD2DRD4GAA | |
| SCHEMBL20625881 | 0.79 | KDM4E (0.40) | CCR2CCR1CCR5CXCR4MAPT | |
| SCHEMBL20625837 | 0.76 | FPR2 (0.41) | CCR2CCR1CCR5CXCR4MAPT | |
| SCHEMBL20625883 | 0.73 | KDM4E (0.39) | CCR2CCR1CCR5CXCR4MAPT | |
| SCHEMBL25680588 | 0.72 | FAAH (0.48) | CCR2CCR1CCR5CXCR4MAPT | |
| SCHEMBL19413330 | 0.71 | HRH3 (0.44) | — | |
| SCHEMBL27462713 | 0.71 | EPHX1 (0.52) | CCR2CCR1CCR5CXCR4MAPT | |
| SCHEMBL28477588 | 0.70 | RIPK1 (0.68) | CNR1RIPK1GAAMEN1KMT2A | |
| SCHEMBL25683476 | 0.70 | CNR1 (0.46) | CCR2CCR1CCR5CXCR4MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10174019-B2 | Substituted 6,5-fused bicyclic heteroaryl compounds | Epizyme, Inc. (US) | 2019-01-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10174019-B2 | Substituted 6,5-fused bicyclic heteroaryl compounds | CYP3A5, PAICS, CYP4B1 | CCR2 967/4885CCR1 2076/4885CCR5 183/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.