Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 4/20 | 0.33 |
| ▸ | CCR2 | P41597 | 2/20 | 0.32 |
| ▸ | CCR1 | P32246 | 1/20 | 0.32 |
| ▸ | CCR5 | P51681 | 1/20 | 0.32 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | ACAT1 | P24752 | 1/20 | 0.32 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | CES2 | O00748 | 1/20 | 0.30 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20625833 | 0.89 | CCR2 (0.39) | EPHX1CCR2CCR1CCR5CXCR4 | |
| SCHEMBL20363209 | 0.72 | FAAH (0.48) | EPHX1CES2 | |
| SCHEMBL20625835 | 0.71 | HRH3 (0.44) | — | |
| SCHEMBL20363242 | 0.71 | FAAH (0.47) | EPHX1CES2 | |
| SCHEMBL20363294 | 0.70 | RAB9A (0.49) | MAPTKDM4EALOX15TSHR | |
| SCHEMBL20363296 | 0.69 | RAB9A (0.51) | GAAMAPTKDM4EALOX15TSHR | |
| SCHEMBL19413256 | 0.69 | S1PR1 (0.33) | EPHX1CCR2CCR1CCR5CXCR4 | |
| SCHEMBL20363229 | 0.69 | RAB9A (0.50) | GAAMAPTKDM4EALOX15TSHR | |
| SCHEMBL23502458 | 0.68 | PLA2G2A (0.50) | ALOX15TSHRMEN1KMT2A | |
| SCHEMBL18743801 | 0.68 | EPHX1 (0.41) | EPHX1CES2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9776996-B2 | Substituted 6,5-fused bicyclic heteroaryl compounds | Epizyme, Inc. (US) | 2017-10-03 | — | — | US | disclosed |