Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RHOA | P61586 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 4/20 | 0.39 |
| ▸ | BRAF | P15056 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | FYN | P06241 | 1/20 | 0.36 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | PHGDH | O43175 | 2/20 | 0.35 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | XBP1 | P17861 | 1/20 | 0.35 |
| ▸ | CCR3 | P51677 | 1/20 | 0.34 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | CASR | P41180 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20632034 | 0.86 | RHOA (0.41) | RHOABRAFFYNCREBBP | |
| SCHEMBL20632880 | 0.83 | DYRK1A (0.39) | RHOABRAFCREBBPPHGDH | |
| SCHEMBL19365696 | 0.81 | RHOA (0.42) | RHOABRAFFYNCREBBPBRD4 | |
| SCHEMBL19670564 | 0.81 | RHOA (0.46) | RHOABRAFFYNCREBBPMAPT | |
| SCHEMBL19670130 | 0.80 | RHOA (0.44) | RHOALMNABRAFMEN1KMT2A | |
| SCHEMBL16238182 | 0.79 | RHOA (0.45) | RHOALMNABRAFMEN1KMT2A | |
| SCHEMBL19670152 | 0.79 | RHOA (0.36) | RHOABRAFFYNCREBBPROCK2 | |
| SCHEMBL20633289 | 0.79 | LMNA (0.39) | LMNABRAFMEN1KMT2AL3MBTL1 | |
| SCHEMBL20632372 | 0.79 | LMNA (0.38) | LMNABRAFMEN1KMT2AL3MBTL1 | |
| SCHEMBL21841333 | 0.78 | RHOA (0.45) | RHOALMNABRAFMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2997029-B1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC (US) | 2019-01-09 | — | — | EP | disclosed |