Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RHOA | P61586 | 1/20 | 0.42 |
| ▸ | BRAF | P15056 | 1/20 | 0.42 |
| ▸ | FYN | P06241 | 1/20 | 0.39 |
| ▸ | CREBBP | Q92793 | 3/20 | 0.38 |
| ▸ | BRD4 | O60885 | 2/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 4/20 | 0.36 |
| ▸ | HTR2C | P28335 | 4/20 | 0.36 |
| ▸ | HTR2B | P41595 | 3/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | GPR142 | Q7Z601 | 1/20 | 0.36 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19670564 | 0.88 | RHOA (0.46) | RHOABRAFFYNCREBBPBRD4 | |
| SCHEMBL20632034 | 0.84 | RHOA (0.41) | RHOABRAFFYNCREBBPCA2 | |
| SCHEMBL19670323 | 0.82 | RHOA (0.44) | RHOABRAFFYNCREBBPBRD4 | |
| SCHEMBL16776385 | 0.81 | BRAF (0.41) | RHOABRAFFYNCREBBPBRD4 | |
| SCHEMBL20632116 | 0.81 | RHOA (0.43) | RHOABRAFFYNCREBBPBRD4 | |
| SCHEMBL21841333 | 0.81 | RHOA (0.45) | RHOABRAFFYNCREBBPBRD4 | |
| SCHEMBL20632880 | 0.79 | DYRK1A (0.39) | RHOABRAFCREBBPCA2CA9 | |
| SCHEMBL16238677 | 0.79 | RHOA (0.44) | RHOABRAFFYNCREBBPBRD4 | |
| SCHEMBL19365824 | 0.79 | KMO (0.39) | FYNCA2CA9HTR2AHTR2C | |
| SCHEMBL19670427 | 0.78 | DYRK1A (0.39) | RHOABRAFCA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9765075-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-09-19 | — | — | US | disclosed |