Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | FYN | P06241 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | XBP1 | P17861 | 1/20 | 0.33 |
| ▸ | BRAF | P15056 | 4/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.32 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20632372 | 0.87 | LMNA (0.38) | LMNAMEN1KMT2AL3MBTL1FYN | |
| SCHEMBL20632116 | 0.79 | RHOA (0.43) | LMNAMEN1KMT2AL3MBTL1FYN | |
| SCHEMBL20632070 | 0.78 | BRAF (0.34) | LMNAFYNPOLBBRAFSMN1; SMN2 | |
| SCHEMBL20632330 | 0.77 | TLR8 (0.36) | LMNAFYNPOLBBRAFHTT | |
| SCHEMBL20633441 | 0.76 | FYN (0.39) | LMNAMEN1KMT2AFYNBRAF | |
| SCHEMBL20633264 | 0.76 | NPC1 (0.31) | BRAFNPC1RAB9ARAF1 | |
| SCHEMBL20632046 | 0.75 | CYP1A2 (0.43) | LMNAMEN1KMT2AL3MBTL1FYN | |
| SCHEMBL20633162 | 0.75 | AURKA (0.38) | LMNAMEN1KMT2AFYNPOLB | |
| SCHEMBL20633005 | 0.75 | LMNA (0.38) | LMNAMEN1KMT2AL3MBTL1FYN | |
| SCHEMBL19669976 | 0.74 | HTR2A (0.52) | LMNAMEN1KMT2AL3MBTL1FYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2997029-B1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC (US) | 2019-01-09 | — | — | EP | disclosed |