Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 3/20 | 0.37 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.37 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 2/20 | 0.34 |
| ▸ | BCR | P11274 | 2/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20632905 | 0.89 | PIK3CG (0.34) | PIK3CAPIK3CGPIK3CDPIK3CBPOLB | |
| SCHEMBL20631458 | 0.88 | FPR3 (0.35) | PIK3CAPIK3CGPIK3CDPIK3CBALDH1A1 | |
| SCHEMBL20632389 | 0.84 | SMN1; SMN2 (0.35) | ALDH1A1KDM4EPKMNPC1RAB9A | |
| SCHEMBL20633094 | 0.83 | PIK3CD (0.33) | PIK3CAPIK3CGPIK3CDPIK3CBPKM | |
| SCHEMBL20632804 | 0.82 | KDM1A (0.38) | ALDH1A1KDM4ELMNACYP3A4KMT2A | |
| SCHEMBL20631944 | 0.81 | KDM1A (0.32) | PIK3CAPIK3CGPIK3CDPIK3CBPKM | |
| SCHEMBL20632355 | 0.81 | CYP11B2 (0.41) | ALDH1A1KDM4ENPC1CYP3A4ACHE | |
| SCHEMBL20632925 | 0.79 | GSK3B (0.36) | ALDH1A1KDM4EPKMNPC1RAB9A | |
| SCHEMBL20631643 | 0.79 | HTR2C (0.41) | KDM4EPKMNPC1RAB9ACYP3A4 | |
| SCHEMBL20632406 | 0.79 | HTR2C (0.43) | ALDH1A1KDM4ELMNAPOLBPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2997029-B1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC (US) | 2019-01-09 | — | — | EP | disclosed |