Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.34 |
| ▸ | AR | P10275 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.34 |
| ▸ | FYN | P06241 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.33 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | KMO | O15229 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20631944 | 0.94 | KDM1A (0.32) | KDM1A | |
| SCHEMBL20633094 | 0.93 | PIK3CD (0.33) | KDM1AKMT2AITGB3ITGA2B | |
| SCHEMBL20633233 | 0.87 | KMT2A (0.36) | KDM1AALDH1A1SMN1; SMN2KDM4EADORA2A | |
| SCHEMBL17655381 | 0.87 | SMN1; SMN2 (0.39) | KDM1AALDH1A1SMN1; SMN2KDM4EAR | |
| SCHEMBL20632146 | 0.86 | TRPA1 (0.35) | KDM1AALDH1A1SMN1; SMN2ARADORA2A | |
| SCHEMBL20632425 | 0.85 | NR3C1 (0.37) | KDM1AARADORA2ATRPA1FYN | |
| SCHEMBL20632389 | 0.84 | SMN1; SMN2 (0.35) | ALDH1A1SMN1; SMN2KDM4EFYNMAPT | |
| SCHEMBL20633162 | 0.83 | AURKA (0.38) | KDM1AALDH1A1SMN1; SMN2FYNMAPT | |
| SCHEMBL20633441 | 0.82 | FYN (0.39) | KDM1AALDH1A1SMN1; SMN2FYNMAPT | |
| SCHEMBL20633005 | 0.82 | LMNA (0.38) | KDM1AALDH1A1SMN1; SMN2FYNMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2997029-B1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC (US) | 2019-01-09 | — | — | EP | disclosed |