Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.33 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.33 |
| ▸ | VCP | P55072 | 1/20 | 0.32 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.32 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.32 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.32 |
| ▸ | KARS1 | Q15046 | 2/20 | 0.32 |
| ▸ | JAK2 | O60674 | 2/20 | 0.32 |
| ▸ | NPY2R | P49146 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | GSK3B | P49841 | 1/20 | 0.31 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.31 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.31 |
| ▸ | KDM5A | P29375 | 1/20 | 0.31 |
| ▸ | FAAH | O00519 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17618578 | 0.90 | TRPV1 (0.37) | CNR2VCPTRPM8TRPV1SIRT2 | |
| SCHEMBL20631923 | 0.85 | PHGDH (0.41) | KARS1MEN1KMT2AALDH1A1 | |
| SCHEMBL20632784 | 0.84 | KARS1 (0.38) | CNR2VCPKARS1GSK3BDYRK1A | |
| SCHEMBL20633225 | 0.82 | BTK (0.34) | CNR2VCPPOLB | |
| SCHEMBL20632191 | 0.81 | USP30 (0.41) | JAK2 | |
| SCHEMBL20633297 | 0.80 | PHGDH (0.36) | CNR2VCPTRPV1KARS1NPY2R | |
| SCHEMBL20633332 | 0.79 | SLC9A1 (0.35) | KARS1MEN1KMT2AFAAH | |
| SCHEMBL16775782 | 0.79 | GRM5 (0.39) | CNR2VCPSIRT2KARS1GSK3B | |
| SCHEMBL22239757 | 0.79 | MEN1 (0.35) | POLBMEN1KMT2AALDH1A1 | |
| SCHEMBL22240057 | 0.79 | MEN1 (0.34) | MEN1KMT2AKDM5AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2997029-B1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC (US) | 2019-01-09 | — | — | EP | disclosed |