Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC9A1 | P19634 | 1/20 | 0.35 |
| ▸ | KARS1 | Q15046 | 2/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 5/20 | 0.33 |
| ▸ | FAAH | O00519 | 1/20 | 0.33 |
| ▸ | BTK | Q06187 | 1/20 | 0.33 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.32 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.32 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.32 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.32 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.32 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.32 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.32 |
| ▸ | MTOR | P42345 | 2/20 | 0.32 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | KMO | O15229 | 1/20 | 0.31 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.31 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20631665 | 0.95 | SLC9A1 (0.35) | SLC9A1KARS1OPRK1FAAHCHRNB2 | |
| SCHEMBL20632411 | 0.88 | ABL1 (0.34) | KARS1FAAHCHRNB2CHRNB4CHRNA3 | |
| SCHEMBL20633316 | 0.85 | OPRK1 (0.35) | OPRK1FAAHMTOREGFR | |
| SCHEMBL16776262 | 0.85 | FAAH (0.39) | SLC9A1FAAHCHRNB2CHRNB4CHRNA3 | |
| SCHEMBL20632784 | 0.84 | KARS1 (0.38) | KARS1EGFRMEN1KMT2AKMO | |
| SCHEMBL20631481 | 0.83 | GAA (0.38) | SLC9A1KARS1FAAHEGFRKMT2A | |
| SCHEMBL20632133 | 0.83 | MPL (0.35) | FAAHCHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL20632826 | 0.83 | FAAH (0.33) | FAAHCHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL17618430 | 0.80 | MPL (0.41) | FAAHCHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL17618517 | 0.80 | MPL (0.41) | FAAHCHRNB2CHRNB4CHRNA3CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2997029-B1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC (US) | 2019-01-09 | — | — | EP | disclosed |