Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 4/20 | 0.42 |
| ▸ | HTR2A | P28223 | 3/20 | 0.42 |
| ▸ | HTR2B | P41595 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 3/20 | 0.40 |
| ▸ | BCR | P11274 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.39 |
| ▸ | PIKFYVE | Q9Y2I7 | 2/20 | 0.38 |
| ▸ | TEK | Q02763 | 1/20 | 0.38 |
| ▸ | BRAF | P15056 | 2/20 | 0.38 |
| ▸ | FYN | P06241 | 2/20 | 0.38 |
| ▸ | KIT | P10721 | 1/20 | 0.38 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 2/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20631532 | 0.94 | HTR2C (0.40) | HTR2CHTR2AHTR2BCYP1A2ABL1 | |
| SCHEMBL20632430 | 0.94 | HTR2C (0.40) | HTR2CHTR2AHTR2BCYP1A2ABL1 | |
| SCHEMBL20633441 | 0.91 | FYN (0.39) | MEN1KMT2AMAPTBRAFFYN | |
| SCHEMBL20633162 | 0.90 | AURKA (0.38) | MEN1KMT2AMAPTFYNKIT | |
| SCHEMBL20632643 | 0.88 | CSF1R (0.38) | MEN1KMT2ABRAFFYNKIT | |
| SCHEMBL20632046 | 0.88 | CYP1A2 (0.43) | HTR2CHTR2ACYP1A2MEN1KMT2A | |
| SCHEMBL20632292 | 0.88 | HTR2C (0.41) | HTR2CHTR2AHTR2BCYP1A2MEN1 | |
| SCHEMBL20633005 | 0.88 | LMNA (0.38) | MEN1KMT2AMAPTBRAFFYN | |
| SCHEMBL20632922 | 0.86 | KDM4E (0.36) | HTR2CHTR2AABL1MEN1KMT2A | |
| SCHEMBL20632024 | 0.86 | RHOA (0.47) | CYP1A2MAPTFYNLMNAMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2997029-B1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC (US) | 2019-01-09 | — | — | EP | disclosed |