Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.51 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.51 |
| ▸ | TMEM97 | Q5BJF2 | 4/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.50 |
| ▸ | THRA | P10827 | 3/20 | 0.50 |
| ▸ | THRB | P10828 | 3/20 | 0.50 |
| ▸ | PARP1 | P09874 | 1/20 | 0.49 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.49 |
| ▸ | NAAA | Q02083 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | KDM5A | P29375 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23889139 | 0.91 | SMN1; SMN2 (0.54) | SMN1; SMN2TMEM97SIGMAR1PARP1MRGPRX4 | |
| SCHEMBL12333454 | 0.85 | USP2 (0.55) | SMN1; SMN2TMEM97SIGMAR1PARP1MRGPRX4 | |
| SCHEMBL20810289 | 0.82 | SPHK2 (0.59) | SMN1; SMN2SPHK2SPHK1PARP1NAAA | |
| SCHEMBL5256827 | 0.82 | SMN1; SMN2 (0.68) | SMN1; SMN2SPHK2SPHK1MRGPRX4NAAA | |
| SCHEMBL5256832 | 0.82 | SMN1; SMN2 (0.68) | SMN1; SMN2SPHK2SPHK1TMEM97SIGMAR1 | |
| SCHEMBL5109753 | 0.81 | LOXL2 (0.54) | SMN1; SMN2TMEM97SIGMAR1PARP1MRGPRX4 | |
| SCHEMBL3061004 | 0.81 | SMN1; SMN2 (0.59) | SMN1; SMN2SPHK2SPHK1MRGPRX4NAAA | |
| SCHEMBL22754705 | 0.80 | PARP1 (0.54) | SMN1; SMN2TMEM97SIGMAR1PARP1MRGPRX4 | |
| SCHEMBL18970272 | 0.80 | SMN1; SMN2 (0.70) | SMN1; SMN2TMEM97SIGMAR1MRGPRX4NAAA | |
| SCHEMBL12055875 | 0.80 | SIGMAR1 (0.59) | SMN1; SMN2TMEM97SIGMAR1PARP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10829501-B2 | Spiroheptane salicylamides and related compounds as inhibitors of ROCK | BRISTOL-MYERS SQUIBB COMPANY (US) | 2020-11-10 | — | — | US | disclosed |
| US-20200131200-A1 | SPIROHEPTANE SALICYLAMIDES AND RELATED COMPOUNDS AS INHIBITORS OF ROCK | BRISTOL MYERS SQUIBB CO (US) | 2020-04-30 | — | — | US | disclosed |
| US-10611776-B2 | Spiroheptane salicylamides and related compounds as inhibitors of rock | BRISTOL-MYERS SQUIBB COMPANY (US) | 2020-04-07 | — | — | US | disclosed |
| US-20190016735-A1 | SPIROHEPTANE SALICYLAMIDES AND RELATED COMPOUNDS AS INHIBITORS OF ROCK | BRISTOL MYERS SQUIBB CO (US) | 2019-01-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10829501-B2 | Spiroheptane salicylamides and related compounds as inhibitors of ROCK | ROCK1, MYLK, RHOA | SMN1; SMN2 823/4885SPHK2 47/4885SPHK1 20/4885 |
| US-20190016735-A1 | SPIROHEPTANE SALICYLAMIDES AND RELATED COMPOUNDS AS INHIBITORS OF ROCK | ROCK1, MYLK, RHOA | SMN1; SMN2 827/4885SPHK2 41/4885SPHK1 19/4885 |
| US-10611776-B2 | Spiroheptane salicylamides and related compounds as inhibitors of rock | ROCK1, MYLK, RHOA | SMN1; SMN2 827/4885SPHK2 41/4885SPHK1 19/4885 |
| US-20200131200-A1 | SPIROHEPTANE SALICYLAMIDES AND RELATED COMPOUNDS AS INHIBITORS OF ROCK | ROCK1, MYLK, RHOA | SMN1; SMN2 823/4885SPHK2 47/4885SPHK1 20/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.