Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX3 | P56373 | 12/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.37 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.36 |
| ▸ | TRPC4 | Q9UBN4 | 2/20 | 0.36 |
| ▸ | TRPC5 | Q9UL62 | 2/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | TRPC1 | P48995 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | GFER | P55789 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20652815 | 0.94 | ADORA3 (0.43) | P2RX3ADORA3TRPC4TRPC5KCNH2 | |
| SCHEMBL24095814 | 0.92 | MAPK1 (0.38) | P2RX3NPSR1MAPK1GFERKMT2A | |
| SCHEMBL24095634 | 0.92 | NPSR1 (0.35) | P2RX3ADORA3NPSR1MAPK1GFER | |
| SCHEMBL20652819 | 0.91 | P2RX3 (0.39) | P2RX3ADORA3PCSK9TRPC4TRPC5 | |
| SCHEMBL20652805 | 0.90 | P2RX3 (0.39) | P2RX3ADORA3PCSK9TRPC4TRPC5 | |
| SCHEMBL20652731 | 0.88 | PKM (0.40) | P2RX3ADORA3PCSK9TRPC4TRPC5 | |
| SCHEMBL20652794 | 0.87 | P2RX3 (0.45) | P2RX3NPSR1KMT2A | |
| SCHEMBL24095572 | 0.86 | ADORA3 (0.41) | P2RX3ADORA3KMT2A | |
| SCHEMBL20652947 | 0.86 | ADORA3 (0.43) | P2RX3ADORA3TRPC4TRPC5KCNH2 | |
| SCHEMBL20652948 | 0.84 | ADORA3 (0.41) | P2RX3ADORA3PCSK9TRPC4TRPC5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3652176-B1 | SUBSTITUTED XANTHINE DERIVATIVES | BOEHRINGER INGELHEIM INT (DE) | 2021-12-15 | — | — | EP | disclosed |
| US-10329292-B2 | Substituted xanthine derivatives | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2019-06-25 | — | — | US | disclosed |
| WO-2019011802-A1 | NOVEL SUBSTITUTED XANTHINE DERIVATIVES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2019-01-17 | — | — | WO | disclosed |
| US-20190016722-A1 | NOVEL SUBSTITUTED XANTHINE DERIVATIVES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2019-01-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10329292-B2 | Substituted xanthine derivatives | TRPC5, TRPV1, TRPC4 | P2RX3 21/4885ADORA3 352/4885PCSK9 730/4885 |
| US-20190016722-A1 | NOVEL SUBSTITUTED XANTHINE DERIVATIVES | TRPC5, TRPC4, TRPV1 | P2RX3 19/4885ADORA3 366/4885PCSK9 998/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.