SCHEMBL20661253 — predicted protein targets

Predicted protein targets (top 20)

	gene	UniProt	supporting neighbours	confidence
▸	BACE1	P56817	1/20	0.32

▸	MAPT	P10636	3/20	0.32

▸	HPGD	P15428	2/20	0.32

▸	KDM4E	B2RXH2	2/20	0.32

▸	ALDH1A1	P00352	1/20	0.32

▸	LMNA	P02545	1/20	0.32

▸	TP53	P04637	1/20	0.32

▸	MAPK1	P28482	1/20	0.32

▸	HSD17B10	Q99714	1/20	0.32

▸	ECE1	P42892	2/20	0.32

▸	ADORA3	P0DMS8	2/20	0.31

▸	UCHL3	P15374	1/20	0.31

▸	GABRA1	P14867	1/20	0.31

▸	GABRA5	P31644	1/20	0.31

▸	GABRA3	P34903	1/20	0.31

▸	GABRA2	P47869	1/20	0.31

▸	GABRA6	Q16445	1/20	0.31

▸	POLB	P06746	2/20	0.30

▸	MEN1	O00255	1/20	0.30

▸	CYP3A4	P08684	1/20	0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL20739358	0.94	BACE1 (0.32)	BACE1MAPTHPGDKDM4EALDH1A1
SCHEMBL20674814	0.89	DPP4 (0.32)	BACE1ECE1UCHL3
SCHEMBL20661230	0.88	UCHL3 (0.31)	BACE1ECE1UCHL3
SCHEMBL20739359	0.87	—	—
Methylene Chloride SCHEMBL20661254	0.87	DPP4 (0.30)	—
SCHEMBL20739365	0.82	—	—
SCHEMBL20661219	0.81	RAD52 (0.31)	MAPTKDM4EPOLBMEN1KMT2A
SCHEMBL20661245	0.75	—	—
SCHEMBL22021445	0.72	DPP4 (0.32)	—
SCHEMBL20674813	0.70	POLB (0.35)	BACE1MAPTHPGDKDM4EALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
US-10781213-B2	Methods for preparing bis-tetrahydroisoquinoline-containing compounds	CALIFORNIA INSTITUTE OF TECHNOLOGY (US)	2020-09-22	—	—	US	disclosed
EP-3655379-A1	METHODS FOR PREPARING BIS-TETRAHYDROISOQUINOLINE-CONTAINING COMPOUNDS	California Institute of Technology (US)	2020-05-27	—	—	EP	disclosed
US-20200157102-A1	Methods for Preparing Bis-Tetrahydroisoquinoline-Containing Compounds	CALIFORNIA INSTITUTE OF TECHNOLOGY	2020-05-21	—	—	US	disclosed
US-20190048009-A1	Methods for Preparing Bis-Tetrahydroisoquinoline-Containing Compounds	CALIFORNIA INSTITUTE OF TECHNOLOGY	2019-02-14	—	—	US	disclosed
WO-2019018539-A1	METHODS FOR PREPARING BIS-TETRAHYDROISOQUINOLINE-CONTAINING COMPOUNDS	CALIFORNIA INSTITUTE OF TECHNOLOGY (US)	2019-01-24	—	—	WO	disclosed
WO-2019018539-A1	METHODS FOR PREPARING BIS-TETRAHYDROISOQUINOLINE-CONTAINING COMPOUNDS	CALIFORNIA INSTITUTE OF TECHNOLOGY (US)	2019-01-24	—	—	WO	disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

Patent	Title	Text reads most about	Predicted target · text-rank
US-20190048009-A1	Methods for Preparing Bis-Tetrahydroisoquinoline-Containing Compounds	SYNCRIP, MYC, RPS27	BACE1 2818/4885MAPT 1668/4885HPGD 1344/4885
US-20200157102-A1	Methods for Preparing Bis-Tetrahydroisoquinoline-Containing Compounds	SYNCRIP, MYC, RPS27	BACE1 2818/4885MAPT 1668/4885HPGD 1344/4885
US-10781213-B2	Methods for preparing bis-tetrahydroisoquinoline-containing compounds	SYNCRIP, MYC, RPS27	BACE1 2818/4885MAPT 1668/4885HPGD 1344/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.