Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20674814 | 0.97 | DPP4 (0.32) | DPP4 | |
| SCHEMBL20661253 | 0.87 | BACE1 (0.32) | — | |
| SCHEMBL20739365 | 0.85 | — | — | |
| SCHEMBL20661230 | 0.83 | UCHL3 (0.31) | — | |
| SCHEMBL20739359 | 0.82 | — | — | |
| SCHEMBL20739358 | 0.81 | BACE1 (0.32) | — | |
| SCHEMBL22021445 | 0.79 | DPP4 (0.32) | DPP4 | |
| SCHEMBL22021443 | 0.77 | DPP4 (0.30) | DPP4 | |
| SCHEMBL20661219 | 0.75 | RAD52 (0.31) | — | |
| SCHEMBL20674813 | 0.66 | POLB (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3655379-B1 | METHODS FOR PREPARING BIS-TETRAHYDROISOQUINOLINE-CONTAINING COMPOUNDS | CALIFORNIA INST OF TECHN (US) | 2023-04-05 | — | — | EP | disclosed |
| US-10781213-B2 | Methods for preparing bis-tetrahydroisoquinoline-containing compounds | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2020-09-22 | — | — | US | disclosed |
| EP-3655379-A1 | METHODS FOR PREPARING BIS-TETRAHYDROISOQUINOLINE-CONTAINING COMPOUNDS | California Institute of Technology (US) | 2020-05-27 | — | — | EP | disclosed |
| US-20200157102-A1 | Methods for Preparing Bis-Tetrahydroisoquinoline-Containing Compounds | CALIFORNIA INSTITUTE OF TECHNOLOGY | 2020-05-21 | — | — | US | disclosed |
| US-20190048009-A1 | Methods for Preparing Bis-Tetrahydroisoquinoline-Containing Compounds | CALIFORNIA INSTITUTE OF TECHNOLOGY | 2019-02-14 | — | — | US | disclosed |
| WO-2019018539-A1 | METHODS FOR PREPARING BIS-TETRAHYDROISOQUINOLINE-CONTAINING COMPOUNDS | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2019-01-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190048009-A1 | Methods for Preparing Bis-Tetrahydroisoquinoline-Containing Compounds | SYNCRIP, MYC, RPS27 | DPP4 4733/4885 |
| US-20200157102-A1 | Methods for Preparing Bis-Tetrahydroisoquinoline-Containing Compounds | SYNCRIP, MYC, RPS27 | DPP4 4733/4885 |
| US-10781213-B2 | Methods for preparing bis-tetrahydroisoquinoline-containing compounds | SYNCRIP, MYC, RPS27 | DPP4 4733/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.