Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 3/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | GFER | P55789 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | ECE1 | P42892 | 2/20 | 0.32 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.31 |
| ▸ | UCHL3 | P15374 | 1/20 | 0.31 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20661253 | 0.94 | BACE1 (0.32) | BACE1MAPTHPGDPOLBKDM4E | |
| SCHEMBL20674814 | 0.83 | DPP4 (0.32) | BACE1ECE1UCHL3 | |
| SCHEMBL20661230 | 0.82 | UCHL3 (0.31) | BACE1ECE1UCHL3 | |
| SCHEMBL20739359 | 0.81 | — | — | |
| Methylene Chloride SCHEMBL20661254 | 0.81 | DPP4 (0.30) | — | |
| SCHEMBL20739365 | 0.77 | — | — | |
| SCHEMBL20661219 | 0.75 | RAD52 (0.31) | MAPTPOLBKDM4EMEN1KMT2A | |
| SCHEMBL20674813 | 0.70 | POLB (0.35) | BACE1MAPTHPGDPOLBKDM4E | |
| SCHEMBL20661245 | 0.69 | — | — | |
| SCHEMBL14927116 | 0.69 | RAC1 (0.42) | MAPTKDM4EALDH1A1HSD17B10ADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10781213-B2 | Methods for preparing bis-tetrahydroisoquinoline-containing compounds | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2020-09-22 | — | — | US | disclosed |
| US-20200157102-A1 | Methods for Preparing Bis-Tetrahydroisoquinoline-Containing Compounds | CALIFORNIA INSTITUTE OF TECHNOLOGY | 2020-05-21 | — | — | US | disclosed |
| US-20190048009-A1 | Methods for Preparing Bis-Tetrahydroisoquinoline-Containing Compounds | CALIFORNIA INSTITUTE OF TECHNOLOGY | 2019-02-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190048009-A1 | Methods for Preparing Bis-Tetrahydroisoquinoline-Containing Compounds | SYNCRIP, MYC, RPS27 | BACE1 2818/4885MAPT 1668/4885HPGD 1344/4885 |
| US-20200157102-A1 | Methods for Preparing Bis-Tetrahydroisoquinoline-Containing Compounds | SYNCRIP, MYC, RPS27 | BACE1 2818/4885MAPT 1668/4885HPGD 1344/4885 |
| US-10781213-B2 | Methods for preparing bis-tetrahydroisoquinoline-containing compounds | SYNCRIP, MYC, RPS27 | BACE1 2818/4885MAPT 1668/4885HPGD 1344/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.