Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.50 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | GPR84 | Q9NQS5 | 4/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14346068 | 1.00 | SLC22A6 (0.50) | SLC22A6GABRR1LMNAMAPTSMN1; SMN2 | |
| SCHEMBL6035097 | 1.00 | SLC22A6 (0.50) | SLC22A6GABRR1LMNAMAPTSMN1; SMN2 | |
| SCHEMBL2066730 | 1.00 | SLC22A6 (0.50) | SLC22A6GABRR1LMNAMAPTSMN1; SMN2 | |
| SCHEMBL14524861 | 0.81 | ALDH1A1 (0.36) | ALDH1A1TDP1 | |
| SCHEMBL6706270 | 0.79 | SLC22A6 (0.46) | SLC22A6GABRR1LMNAMAPTSMN1; SMN2 | |
| SCHEMBL819583 | 0.78 | ALDH1A1 (0.38) | SMN1; SMN2ALDH1A1TDP1 | |
| SCHEMBL20788028 | 0.77 | FOLH1 (0.43) | SLC22A6SMN1; SMN2TDP1 | |
| SCHEMBL8570633 | 0.77 | BHMT (0.37) | SLC22A6SMN1; SMN2ALDH1A1TDP1CYP1A2 | |
| SCHEMBL5056493 | 0.76 | GPR84 (0.47) | SLC22A6GABRR1LMNAMAPTSMN1; SMN2 | |
| SCHEMBL1139716 | 0.76 | GPR84 (0.47) | SLC22A6GABRR1LMNAMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080289056-A1 | CHEMOENZYMATIC METHODS FOR THE SYNTHESIS OF STATINS AND STATIN INTERMEDIATES | VERENIUM CORPORATION (US) | 2008-11-20 | — | — | US | claimed |
| EP-1625223-A2 | CHEMOENZYMATIC METHODS FOR THE SYNTHESIS OF STATINS AND STATIN INTERMEDIATES | Diversa Corporation (US) | 2006-02-15 | — | — | EP | claimed |
| US-20050153407-A1 | Chemoenzymatic methods for the synthesis of statins and stain intermediates | VERENIUM CORPORATION | 2005-07-14 | — | — | US | claimed |
| WO-2004027075-A2 | CHEMOENZYMATIC METHODS FOR THE SYNTHESIS OF STATINS AND STAIN INTERMEDIATES | DIVERSA CORPORATION (US) | 2004-04-01 | — | — | WO | claimed |
| US-8148324-B2 | Aldolases, nucleic acids encoding them; improving thermal stability of enzyme; biosynthesis of atorvastatin, rosuvastatin, fluvastatin starting from e.g. acetaldehyde and chloroacetaldehyde, using enzyme 2-deoxyribose-5-phosphate aldolase (DERA) to form pyran intermediate | VERENIUM CORPORATION (US) | 2012-04-03 | — | — | US | disclosed |
| US-8148324-B2 | Aldolases, nucleic acids encoding them; improving thermal stability of enzyme; biosynthesis of atorvastatin, rosuvastatin, fluvastatin starting from e.g. acetaldehyde and chloroacetaldehyde, using enzyme 2-deoxyribose-5-phosphate aldolase (DERA) to form pyran intermediate | VERENIUM CORPORATION (US) | 2012-04-03 | — | — | US | disclosed |
| US-20080289056-A1 | CHEMOENZYMATIC METHODS FOR THE SYNTHESIS OF STATINS AND STATIN INTERMEDIATES | VERENIUM CORPORATION (US) | 2008-11-20 | — | — | US | disclosed |
| US-20080289056-A1 | CHEMOENZYMATIC METHODS FOR THE SYNTHESIS OF STATINS AND STATIN INTERMEDIATES | VERENIUM CORPORATION (US) | 2008-11-20 | — | — | US | disclosed |
| US-7414119-B2 | Aldolases, nucleic acids encoding them and methods for making and using them | VERENIUM CORPORATION (US) | 2008-08-19 | — | — | US | disclosed |
| EP-1625223-A2 | CHEMOENZYMATIC METHODS FOR THE SYNTHESIS OF STATINS AND STATIN INTERMEDIATES | Diversa Corporation (US) | 2006-02-15 | — | — | EP | disclosed |
| US-20050153407-A1 | Chemoenzymatic methods for the synthesis of statins and stain intermediates | VERENIUM CORPORATION | 2005-07-14 | — | — | US | disclosed |
| WO-2004027075-A2 | CHEMOENZYMATIC METHODS FOR THE SYNTHESIS OF STATINS AND STAIN INTERMEDIATES | DIVERSA CORPORATION (US) | 2004-04-01 | — | — | WO | disclosed |