Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS2 | P35228 | 6/20 | 0.96 |
| ▸ | NOS1 | P29475 | 5/20 | 0.63 |
| ▸ | NOS3 | P29474 | 5/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.63 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.63 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.63 |
| ▸ | GRIN2B | Q13224 | 9/20 | 0.61 |
| ▸ | GRIN1 | Q05586 | 6/20 | 0.61 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.55 |
| ▸ | GRIN3B | O60391 | 2/20 | 0.55 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.55 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.55 |
| ▸ | GRIN3A | Q8TCU5 | 2/20 | 0.55 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14291059 | 1.00 | NOS2 (0.96) | NOS2NOS1NOS3ALDH1A1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL4737504 | 0.98 | NOS2 (0.92) | NOS2NOS1NOS3ALDH1A1SMN1; SMN2 | |
| Butylamine SCHEMBL9579993 | 0.86 | NOS2 (0.71) | NOS2NOS1NOS3ALDH1A1SMN1; SMN2 | |
| SCHEMBL104888 | 0.81 | NOS2 (0.65) | NOS2NOS1NOS3ALDH1A1SMN1; SMN2 | |
| SCHEMBL22068858 | 0.81 | NOS2 (0.65) | NOS2NOS1NOS3ALDH1A1SMN1; SMN2 | |
| SCHEMBL45769 | 0.81 | GRIN2B (0.68) | NOS2SMN1; SMN2GRIN2BGRIN1GRIN2D | |
| SCHEMBL22068857 | 0.81 | NOS2 (0.65) | NOS2NOS1NOS3ALDH1A1SMN1; SMN2 | |
| SCHEMBL7206541 | 0.79 | GRIN2B (0.65) | NOS2SMN1; SMN2GRIN2BGRIN1GRIN2D | |
| Hydrochloric Acid SCHEMBL4629266 | 0.79 | GRIN2B (0.72) | NOS2SMN1; SMN2GRIN2BGRIN1GRIN2D | |
| SCHEMBL1796013 | 0.78 | NOS2 (0.62) | NOS2GRIN2BGRIN1GRIN2DGRIN3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220220111-A1 | 1,8-NAPHTHYRIDINONE COMPOUNDS AND USES THEREOF | NUVATION BIO OPERATING COMPANY INC (US) | 2022-07-14 | — | — | US | disclosed |
| US-10793561-B2 | 1,8-naphthyridinone compounds and uses thereof | NUVATION BIO INC. (US) | 2020-10-06 | — | — | US | disclosed |
| US-20190023702-A1 | 1,8-NAPHTHYRIDINONE COMPOUNDS AND USES THEREOF | SAGARD HOLDINGS MANAGER LP, AS ADMINISTRATIVE AGENT (CA) | 2019-01-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220220111-A1 | 1,8-NAPHTHYRIDINONE COMPOUNDS AND USES THEREOF | NME1, ADORA2A, GPR68 | NOS2 3052/4885NOS1 2413/4885NOS3 3162/4885 |
| US-10793561-B2 | 1,8-naphthyridinone compounds and uses thereof | NME1, ADORA2A, GPR68 | NOS2 3052/4885NOS1 2413/4885NOS3 3162/4885 |
| US-20190023702-A1 | 1,8-NAPHTHYRIDINONE COMPOUNDS AND USES THEREOF | NME1, ADORA2A, GPR68 | NOS2 3052/4885NOS1 2413/4885NOS3 3162/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.