Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | MMP2 | P08253 | 2/20 | 0.49 |
| ▸ | CNR1 | P21554 | 1/20 | 0.47 |
| ▸ | CNR2 | P34972 | 1/20 | 0.47 |
| ▸ | LTA4H | P09960 | 1/20 | 0.45 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.43 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.43 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.43 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | GSR | P00390 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HRH1 | P35367 | 1/20 | 0.41 |
| ▸ | CASR | P41180 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13598088 | 0.92 | MMP2 (0.56) | LMNAMMP2LTA4HDPP8DPP9 | |
| SCHEMBL11518823 | 0.92 | MMP2 (0.56) | LMNAMMP2LTA4HDPP8DPP9 | |
| SCHEMBL30426371 | 0.86 | MMP2 (0.53) | MMP2LTA4H | |
| SCHEMBL9614499 | 0.81 | LMNA (0.61) | LMNAMMP2CNR1CNR2SLC6A9 | |
| SCHEMBL9614501 | 0.81 | LMNA (0.61) | LMNAMMP2CNR1CNR2SLC6A9 | |
| SCHEMBL7313780 | 0.81 | POLB (0.55) | LMNACNR2DPP8DPP9DPP7 | |
| SCHEMBL7313784 | 0.81 | POLB (0.55) | LMNACNR2DPP8DPP9DPP7 | |
| SCHEMBL23052552 | 0.80 | HTR2A (0.51) | LMNAMMP2CNR1CNR2HTR2A | |
| SCHEMBL25492218 | 0.80 | MMP2 (0.53) | MMP2 | |
| SCHEMBL25492255 | 0.79 | MMP2 (0.52) | MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8278099-B1 | Monoclonal antibody to human thrombopoietin | GENENTECH, INC. (US) | 2012-10-02 | — | — | US | disclosed |
| US-8241900-B1 | mpl ligand | GENENTECH, INC. (US) | 2012-08-14 | — | — | US | disclosed |
| US-8193323-B1 | mpl ligand (thrombopoietin), active fragments thereof, and fusion proteins and compositions comprising mpl ligand and other cytokines | GENENTECH, INC. (US) | 2012-06-05 | — | — | US | disclosed |
| US-8192955-B1 | Nucleic acids encoding MPL ligand (thrombopoietin), variants, and fragments thereof | GENENTECH, INC. (US) | 2012-06-05 | — | — | US | disclosed |
| US-8178107-B1 | Method of treatment of thrombocytopenia or risk thereof using MPL ligand (thrombopoietin), variants, and fragments thereof | GENENTECH, INC. (US) | 2012-05-15 | — | — | US | disclosed |
| US-8147844-B1 | Mpl ligand (thrombopoietin), nucleic acids encoding such, and methods of treatment using mpl ligand | GENENTECH, INC. (US) | 2012-04-03 | — | — | US | disclosed |
| EP-0738323-A1 | THROMBOPOIETIN | GENENTECH, INC. (US) | 1996-10-23 | — | — | EP | disclosed |
| WO-1995018858-A1 | THROMBOPOIETIN | GENENTECH, INC. (US) | 1995-07-13 | — | — | WO | disclosed |