Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 1/20 | 0.49 |
| ▸ | ACHE | P22303 | 10/20 | 0.49 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.46 |
| ▸ | BCHE | P06276 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | GLA | P06280 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | CASP1 | P29466 | 2/20 | 0.43 |
| ▸ | CASP7 | P55210 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
| ▸ | NQO2 | P16083 | 1/20 | 0.43 |
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
| ▸ | DRD1 | P21728 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4821612 | 0.78 | MAPT (0.51) | DHODHMAPTKDM4EALDH1A1HPGD | |
| SCHEMBL27952809 | 0.75 | MTOR (0.48) | ADORA2ABTKRAB9ANPC1 | |
| SCHEMBL2713912 | 0.73 | S100A4 (0.49) | BTKRAB9ANPC1 | |
| SCHEMBL8818671 | 0.72 | TGFBR1 (0.49) | DHODHMAPTALDH1A1LMNAPOLB | |
| SCHEMBL13422264 | 0.71 | DHODH (0.53) | DHODHMAPTALDH1A1BTKRAB9A | |
| SCHEMBL27944099 | 0.70 | MTOR (0.49) | ADORA2ABTKRAB9ANPC1 | |
| SCHEMBL18039110 | 0.70 | MTOR (0.41) | BTKRAB9ANPC1 | |
| SCHEMBL17492275 | 0.69 | NPC1 (0.41) | DHODHMAPTKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL4056518 | 0.68 | DHODH (0.54) | DHODHMAPTALDH1A1CASP1BTK | |
| SCHEMBL27915475 | 0.68 | ADORA2A (0.51) | ACHEADORA2ABCHEMAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103030637-A | Imidazole quinoline derivative, and pharmaceutically acceptable salts thereof, preparation method thereof and application thereof on medicines | SHANGHAI HENGRUI PHARM CO LTD | 2013-04-10 | — | — | CN | disclosed |
| EP-2438063-A1 | 1H-IMIDAZO[4,5-C]QUINOLINONE COMPOUNDS, USEFUL FOR THE TREATMENT OF PROLIFERATIVE DISEASES | Novartis AG (CH) | 2012-04-11 | — | — | EP | disclosed |